| Gadofluorine M-enhanced Magnetic Resonance Imaging of Inflammatory Bowel Disease: Quantitative Analysis and Histologic Correlation in a Rat Model. | |
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MedLine Citation:
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PMID: 21512398 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES:: To determine the colonic mural enhancement in a rat model of inflammatory bowel disease (IBD) using gadofluorine M- and diethylenetriamine pentaacetic acid (Gd-DTPA)-enhanced magnetic resonance (MR) imaging, and to correlate the degree of enhancement with the histopathologic severity of the disease. MATERIALS AND METHODS:: This study was approved by our hospital's institutional animal care and use committee. A total of 44 rats with 2 grades (mild, n = 17; and severe, n = 27) of dinitrobenzene sulfonic acid (DNBS)-induced IBD and 13 rats without IBD, were examined using a 2.4-T, small animal MR scanner. T2- and T1-weighted MR images were acquired, and sequential T1-weighted MR imaging was then performed immediately and again 15, 45, 60, and 90 minutes, and 24 hours after intravenous -injection of either gadofluorine M- or Gd-DTPA (0.1 mmol Gd/kg body weight). The signal-to-noise ratios and enhancement ratios (ER) of the colon wall were measured. For paired and group comparisons of the histopathology and MR imaging data, the Wilcoxon- and the Mann-Whitney U tests were used, and the multifactorial analysis of variance test was used to compare the time courses of the ERs. RESULTS:: Gadofluorine M injection resulted in significant differences in the ER of noninflamed, mildly inflamed, and severely inflamed colon wall at any time up to 24 hours after contrast injection (ER at 24 hours 2.0 ± 1.2; 10.1 ± 4.3; and 49.7 ± 10.8, respectively; P < 0.01). After Gd-DTPA injection, significant differences were observed in the ER of inflamed and noninflamed bowel at 15, 45, and 60 minutes (P < 0.01); however, no significant differences in mildly and severely inflamed bowel were observed at any time. In contrast to Gadofluorine M, there was no prolonged contrast enhancement in the inflamed colon wall after intravenous injection of Gd-DTPA (ER at 24 hours 1.6 ± 1.3; 3.4 ± 2.7; and 3.3 ± 1.6, respectively; n.s.). CONCLUSIONS:: Gadofluorine M-enhanced MR imaging shows a higher correlation of the wall enhancement and histopathology grading in an IBD rat model than does Gd-DTPA-enhanced imaging. |
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Authors:
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Bernd B Frericks; Anja A Kühl; Christoph Loddenkemper; Andrea Stroux; Steffi Valdeig; Birgit Hotz; Bernd Misselwitz; Jörg C Hoffmann; Frank K Wacker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
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Title: Investigative radiology Volume: - ISSN: 1536-0210 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Radiology and Nuclear Medicine, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; †Institute of Pathology/Research Center ImmunoSciences (RCIS), Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; ‡Department of Biostatistics and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; §Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD; ¶Department of Surgery, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; ∥Bayer-Schering-Pharma, Berlin, Germany; and **Medizinische Klinik I, St. Marienkrankenhaus, Ludwigshafen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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