Document Detail


Gabapentin for relief of spasticity associated with multiple sclerosis.
MedLine Citation:
PMID:  9798839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of a recently released anticonvulsant, gabapentin, in the treatment of spasticity in two patients with multiple sclerosis is reported. Gabapentin was chosen because of its GABA-ergic effect and because previously reported studies have shown that it is well tolerated compared with other GABA-mimetic medication. Satisfactory release of spasticity with significant improvement of functional outcome was noted in both cases. Both patients were first treated with gabapentin for one month at 300 mg per day and then, with no reported side-effects, at 400 mg per day. Before treatment, spasticity (graded with modified Ashworth Scale) in one patient was 3 for left lower and 2 for right lower limbs, and Expanded Disability Status Scale (EDSS) was 7; ambulation was limited to a few steps with a standard walker. After two weeks of treatment, spasticity was 2 and 1 for the left and right lower limbs, respectively. At three-month intervals, spasticity was +1 for left and 1 for right lower limbs, and EDSS was 6; the patient could ambulate 75 to 100 m with a standard walker. In the second patient, spasticity before treatment was 2 for both lower and left upper limbs. EDSS was 5.5, and ambulation was confined to 100 m with a cane. Spasticity improved to +1 in lower and 1 in left upper limbs after two weeks and to 1 and normal after three months. At three months, EDSS was 3 and the patient could ambulate for long distances without an assistive device. We suggest that gabapentin can be used effectively to decrease spasticity without significant side effects in patients with multiple sclerosis.
Authors:
A Dunevsky; A B Perel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  77     ISSN:  0894-9115     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1998-11-16     Completed Date:  1998-11-16     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  451-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Rehabilitation Medicine, Kingsbrook Jewish Medical Center, Brooklyn, New York 11203, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetates / administration & dosage,  therapeutic use*
Adult
Amines*
Anticonvulsants / administration & dosage,  therapeutic use*
Cyclohexanecarboxylic Acids*
Female
Humans
Male
Middle Aged
Multiple Sclerosis / drug therapy*
Muscle Spasticity / drug therapy*
Parasympatholytics / administration & dosage,  therapeutic use*
gamma-Aminobutyric Acid*
Chemical
Reg. No./Substance:
0/Acetates; 0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 0/Parasympatholytics; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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