| Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations. | |
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MedLine Citation:
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PMID: 21505480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2 hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression. |
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Authors:
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Ulrike Hoffmann; Jeong Hyun Lee; Tao Qin; Katharina Eikermann-Haerter; Cenk Ayata |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-04-20 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-01 Completed Date: 2011-09-12 Revised Date: 2013-06-11 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1578-82 Citation Subset: IM |
Affiliation:
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Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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therapeutic use* Animals Anticonvulsants / therapeutic use* Brain / drug effects*, pathology*, physiopathology Brain Infarction / pathology, physiopathology, prevention & control Brain Ischemia / pathology*, physiopathology, prevention & control* Cortical Spreading Depression / drug effects Cyclohexanecarboxylic Acids / therapeutic use* Ischemic Attack, Transient / pathology, physiopathology, prevention & control Male Mice Mice, Inbred C57BL gamma-Aminobutyric Acid / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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NS055104/NS/NINDS NIH HHS; NS061505/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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