Document Detail

Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.
MedLine Citation:
PMID:  21505480     Owner:  NLM     Status:  MEDLINE    
Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200  mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2  hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.
Ulrike Hoffmann; Jeong Hyun Lee; Tao Qin; Katharina Eikermann-Haerter; Cenk Ayata
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-20
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  31     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-01     Completed Date:  2011-09-12     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1578-82     Citation Subset:  IM    
Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
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MeSH Terms
Amines / therapeutic use*
Anticonvulsants / therapeutic use*
Brain / drug effects*,  pathology*,  physiopathology
Brain Infarction / pathology,  physiopathology,  prevention & control
Brain Ischemia / pathology*,  physiopathology,  prevention & control*
Cortical Spreading Depression / drug effects
Cyclohexanecarboxylic Acids / therapeutic use*
Ischemic Attack, Transient / pathology,  physiopathology,  prevention & control
Mice, Inbred C57BL
gamma-Aminobutyric Acid / therapeutic use*
Grant Support
Reg. No./Substance:
0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

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