Document Detail


Gabapentin markedly reduces acetic acid-induced visceral nociception.
MedLine Citation:
PMID:  12606919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Gabapentin has recently been used clinically as an antihyperalgesic agent to treat certain neuropathic pain states. The aim of this study is to test whether gabapentin is able to inhibit responses to peritoneal irritation-induced visceral pain and to examine the effect of gabapentin on spinal cord amino acid release.
METHODS: The acetic acid-induced writhing assay was used in rats to determine the degree of antinociception. The rats received an intraperitoneal injection of acetic acid 40 min after intraperitoneal administration of vehicle or gabapentin (50, 100, or 200 mg/kg). Cerebrospinal fluid dialysate was collected by microdialysis from the spinal subarachnoid space in anesthetized rats. Acetic acid-induced release of amino acids into the dialysate, including glutamate, aspartate, serine, glutamine, and glycine, following intraperitoneal injection of acetic acid was evaluated by measurements of changes in the concentrations of these amino acids. The effects of pretreatment with saline or gabapentin (100 mg/kg intraperitoneal) on amino acid release were compared.
RESULTS: Gabapentin reduced writhing responses in a dose-related fashion. Dialysate concentrations of glutamate, aspartate, and serine increased significantly following intraperitoneal injection of acetic acid, while glutamine and glycine concentrations were not increased significantly. When compared to saline-treated rats, animals pretreated with 100 mg/kg gabapentin showed suppression of the acetic acid-induced increases in glutamate, aspartate, and serine concentrations.
CONCLUSIONS: These data demonstrate that gabapentin effectively inhibits acetic acid-induced nociception, and the antinociceptive effect of gabapentin correlates with the suppression of noxious-evoked release of excitatory amino acids in the spinal cord.
Authors:
Yi Feng; Minglei Cui; William D Willis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  98     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-27     Completed Date:  2003-03-27     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  729-33     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, Peking University People's Hospital, Beijing, PR China.
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MeSH Terms
Descriptor/Qualifier:
Acetates / pharmacology*
Amines*
Analgesics / pharmacology*
Animals
Calcium / metabolism
Cyclohexanecarboxylic Acids*
Excitatory Amino Acids / secretion
Male
Pain / drug therapy*
Rats
Rats, Sprague-Dawley
Viscera
gamma-Aminobutyric Acid*
Grant Support
ID/Acronym/Agency:
NS09743/NS/NINDS NIH HHS; NS11255/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Acetates; 0/Amines; 0/Analgesics; 0/Cyclohexanecarboxylic Acids; 0/Excitatory Amino Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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