| Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. | |
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MedLine Citation:
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PMID: 8047279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Membrane potential changes of rat neonatal optic nerves were studied in a sucrose-gap chamber. Nipecotic acid (NPA), which blocks uptake and promotes release of GABA, resulted in a bicuculline-sensitive depolarization (3.08 +/- 0.3 mV, n = 5). Pretreatment of the nerves with the anticonvulsant gabapentin (100 microM for 1 h) resulted in a near doubling of the NPA-induced depolarization (6.64 +/- 0.54 mV, n = 5). Gabapentin itself did not alter membrane potential, nor did brief applications of gabapentin enhance the NPA- or GABA-induced depolarization. Thus, gabapentin appears to enhance the releasable pool of GABA in this CNS neural system. These results have implications for the mechanism of the anticonvulsant properties of gabapentin. |
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Authors:
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J D Kocsis; O Honmou |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 169 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-09-01 Completed Date: 1994-09-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, Yale University School of Medicine, New Haven, CT 06516. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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pharmacology* Action Potentials / drug effects Amines* Animals Animals, Newborn / metabolism* Anticonvulsants / pharmacology* Bicuculline / pharmacology Cyclohexanecarboxylic Acids* Membrane Potentials / drug effects Neuromuscular Depolarizing Agents / pharmacology* Nipecotic Acids / pharmacology Optic Nerve / drug effects* Proline* / analogs & derivatives* Rats Rats, Wistar Receptors, GABA-A / antagonists & inhibitors, drug effects, metabolism gamma-Aminobutyric Acid / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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NS 06208/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 0/Neuromuscular Depolarizing Agents; 0/Nipecotic Acids; 0/Receptors, GABA-A; 147-85-3/Proline; 485-49-4/Bicuculline; 498-95-3/nipecotic acid; 56-12-2/gamma-Aminobutyric Acid; 56879-46-0/homoproline; 60142-96-3/gabapentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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