| Gabapentin in childhood epilepsy: a prospective evaluation of efficacy and safety. | |
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MedLine Citation:
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PMID: 10604603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy and safety of gabapentin (GBP) in partial epilepsy in children. METHODS: We performed a prospective open label add-on study in 52 children and adolescents (age 1.8-17.5 years, mean 11.1 years) with refractory partial seizures. Gabapentin was added to one other baseline drug and the efficacy was rated according to seizure type and frequency. RESULTS: The GBP dose ranged from 26 to 78 mg/kg per day (mean 52 mg/kg per day) and was well tolerated in most patients. The seizure frequency remained unchanged in 34 patients (65%). We saw a provocation of seizures in three children (6%). Initially 15 patients (29%) benefited from GBP: five (10%) with a seizure reduction of 50-74%, seven (13%) with a reduction of 75-99% and three (6%) became seizure free. All but three experienced a development of tolerance within the next weeks to months. CONCLUSIONS: Although gabapentin seems also to be safe in children, the efficacy in refractory partial seizures was disappointing. |
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Authors:
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E Korn-Merker; P Borusiak; H E Boenigk |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Epilepsy research Volume: 38 ISSN: 0920-1211 ISO Abbreviation: Epilepsy Res. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-01-24 Completed Date: 2000-01-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 27-32 Citation Subset: IM |
Affiliation:
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Kinderklinik Kidron, Epilepsiezentrum Bethel, Bielefeld, Germnany. kme@neuro.mara.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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adverse effects,
therapeutic use* Adolescent Amines* Anticonvulsants / adverse effects, therapeutic use* Child Child, Preschool Cyclohexanecarboxylic Acids* Drug Resistance Drug Therapy, Combination Epilepsy / drug therapy* Female Humans Infant Male Prospective Studies gamma-Aminobutyric Acid* |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 60142-96-3/gabapentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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