Document Detail

Gabapentin attenuates the pressor response to direct laryngoscopy and tracheal intubation.
MedLine Citation:
PMID:  16595614     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Laryngoscopy and tracheal intubation increase blood pressure and heart rate (HR). The aim of the present study was to investigate the effect of gabapentin when given before operation on the haemodynamic responses to laryngoscopy and intubation.
METHODS: Forty-six patients undergoing abdominal hysterectomy for benign disease were randomly allocated to receive gabapentin 1,600 mg or placebo capsules at 6 hourly intervals starting the day (noon) before surgery. Anaesthesia was induced with propofol and cis-atracurium. Systolic, diastolic arterial blood pressures (SAP, DAP) and heart rate (HR) were recorded before and after the anaesthetic and 0, 1, 3, 5 and 10 min after tracheal intubation.
RESULTS: SAP was significantly lower in the gabapentin vs the control group 0, 1, 3, 5 and 10 min after intubation [128 (27) vs 165 (41), P=0.001, 121 (14) vs 148 (29), P=0.0001, 115 (13) vs 134 (24), P=0.002, 111 (12) vs 126 (19), P=0.004 and 108 (12) vs 124 (17), P=0.001 respectively]. DAP also was lower in the gabapentin group 0, 1, 3, and 10 min after intubation [81 (18) vs 104 (19), P=0.0001, 77 (9) vs 91 (16), P=0.001, 71 (10) vs 84 (13), P=0.001 and 67 (10) vs 79 (12), P=0.004]. HR did not differ between the two groups at any time [82 (11) vs 83 (15), 79 (10) vs 80 (12), 86 (17) vs 92 (10), 82 (11) vs 88 (10), 81 (12) vs 81 (11), 77 (13) vs 79 (13), and 75 (15) vs 78 (12)].
CONCLUSION: Gabapentin, under the present study design attenuates the pressor response but not the tachycardia associated with laryngoscopy and tracheal intubation.
A Fassoulaki; A Melemeni; A Paraskeva; G Petropoulos
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-04-04
Journal Detail:
Title:  British journal of anaesthesia     Volume:  96     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-15     Completed Date:  2006-07-12     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  769-73     Citation Subset:  IM    
Department of Anaesthesiology, Aretaieio Hospital, Medical School, University of Athens, 76 Vassilissis Avenue, 11528 Athens, Greece.
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MeSH Terms
Amines / pharmacology*
Anesthetics, Intravenous
Blood Pressure / drug effects*
Cardiovascular Agents / pharmacology*
Cyclohexanecarboxylic Acids / pharmacology*
Double-Blind Method
Heart Rate / drug effects
Intubation, Intratracheal*
Middle Aged
Preanesthetic Medication
gamma-Aminobutyric Acid / pharmacology*
Reg. No./Substance:
0/Amines; 0/Anesthetics, Intravenous; 0/Cardiovascular Agents; 0/Cyclohexanecarboxylic Acids; 2078-54-8/Propofol; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

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