| GWAS and its impact on elucidating the etiology of diabetes. | |
| | |
MedLine Citation:
|
PMID: 21630414 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It has proven to be challenging to isolate the genes underlying the genetic component conferring susceptibility to type 1 and type 2 diabetes. Unlike previous approaches, 'genome wide association studies' (GWAS) have extensively delivered on the promise of uncovering genetic determinants of complex disease, with a number of novel disease-associated variants being largely replicated by independent groups. This review provides an overview of these recent breakthroughs in the context of type 1 and type 2 diabetes, and outlines strategies on how these findings will be applied to impact clinical care for these two highly prevalent disorders. Copyright © 2011 John Wiley & Sons, Ltd. |
| | |
Authors:
|
Hakon Hakonarson; Struan F A Grant |
Related Documents
:
|
7010454 - Prostacyclin and blood glucose levels in humans and rabbits. 2615424 - Hypoglycemic activity of several seaweed extracts. 21524684 - Differential effects of igf-i, igf-ii and insulin in human preadipocytes and adipocytes... 6226124 - Potentiation of thioacetamide-induced hepatotoxicity in alloxan- and streptozotocin-dia... 16263044 - Implementing a new diabetes resource for wisconsin schools and families. 2611574 - Abnormal eating attitudes in young insulin-dependent diabetics. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-1 |
Journal Detail:
|
Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
|
The Center for Applied Genomics and Division of Human Genetics, the Abramson Research Center of the Joseph Stokes Jr. Research Institute, The Children's Hospital of Philadelphia; Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA. hakonarson@email.chop.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alternating Current Measurements in Scanning Electrochemical Microscopy, Part?2: Detection of Adsorb...
Next Document: Generation of transgenic dogs that conditionally express green fluorescent protein.