| GW bodies, microRNAs and the cell cycle. | |
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MedLine Citation:
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PMID: 16418578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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GW bodies (GWBs) are cytoplasmic foci initially identified through the use of an autoimmune serum targeting the marker protein, GW182. GWBs were first considered as both storage centers for a specific subset of mRNAs and degradation sites for mRNAs. Interestingly, they are known to vary in size and number throughout the cell cycle and are largest in size and most abundant in number during the late S and G2 phases. Recent studies have linked RNA interference to GWBs, in that disruption or disassembly of GWBs was demonstrated to impair siRNA and miRNA silencing activity. As miRNAs are implicated in the regulation of cell cycle progression and cell proliferation, it is very likely that GWBs, the critical intracellular structures for miRNA function, may very well be also linked to this cellular process. |
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Authors:
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Shangli Lian; Andrew Jakymiw; Theophany Eystathioy; John C Hamel; Marvin J Fritzler; Edward K L Chan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-02-14 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-15 Completed Date: 2007-04-24 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 242-5 Citation Subset: IM |
Affiliation:
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Department of Oral Biology, University of Florida, Gainesville, Florida 32610-0424, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantigens
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genetics,
metabolism Cell Cycle / physiology* Cytoplasmic Structures / metabolism* Hela Cells Humans Lamin Type A / genetics, metabolism MicroRNAs / genetics, metabolism* RNA Interference RNA Stability RNA, Messenger / metabolism Transfection |
| Grant Support | |
ID/Acronym/Agency:
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AI39645/AI/NIAID NIH HHS; AI47859/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantigens; 0/Lamin Type A; 0/MicroRNAs; 0/RNA, Messenger; 0/autoantigen GW182, human; 0/lamin C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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