| GTP requirement for inositol-1,4,5-trisphosphate-induced Ca2+ release from sarcoplasmic reticulum in smooth muscle. | |
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MedLine Citation:
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PMID: 3495274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined inositol-1,4,5-trisphosphate (IP3)-induced Ca2+ release from the sarcoplasmic reticulum (SR) in the skinned vascular smooth muscle. The amount of Ca2+ in the SR was estimated indirectly by caffeine-induced contraction of the skinned preparation. The Ca2+ release from the SR by IP3 required GTP. A non-hydrolyzable analogue of GTP, guanosine 5'-(beta gamma-imido) triphosphate (GppNHp) could substitute for GTP in the IP3-induced Ca2+ release. These results suggest an involvement of GTP-binding protein in the mechanism of Ca2+ release from the SR by IP3 in smooth muscle. |
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Authors:
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K Saida; C van Breemen |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 144 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-06-25 Completed Date: 1987-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1313-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caffeine / pharmacology Calcium / metabolism* Guanosine Triphosphate / pharmacology* Guanylyl Imidodiphosphate / pharmacology Inositol 1,4,5-Trisphosphate Inositol Phosphates / pharmacology* Isometric Contraction Kinetics Mesenteric Arteries / drug effects, metabolism Muscle, Smooth, Vascular / drug effects, metabolism* Rabbits Sarcoplasmic Reticulum / drug effects, metabolism* Sugar Phosphates / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Inositol Phosphates; 0/Sugar Phosphates; 34273-04-6/Guanylyl Imidodiphosphate; 58-08-2/Caffeine; 7440-70-2/Calcium; 85166-31-0/Inositol 1,4,5-Trisphosphate; 86-01-1/Guanosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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