| GTP gamma S and forskolin-stimulated adenylyl cyclase activity in post-mortem brain from depressed suicides and controls. | |
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MedLine Citation:
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PMID: 9154249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have measured basal, guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and forskolin-stimulated adenylyl cyclase activity in samples of frontal and parietal cortex obtained at post-mortem from suicides, with a firm retrospective diagnosis of depression. The suicides were divided into those free of antidepressants and those receiving antidepressants. Each suicide was individually compared to a gender and age-matched control. Although we found no significant differences in adenylyl cyclase activity between controls and either antidepressant-free or antidepressant-treated suicides, there was a trend for lower stimulated adenylyl cyclase activity in suicides. |
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Authors:
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S Lowther; M R Crompton; C L Katona; R W Horton |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular psychiatry Volume: 1 ISSN: 1359-4184 ISO Abbreviation: Mol. Psychiatry Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-06-09 Completed Date: 1997-06-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9607835 Medline TA: Mol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 470-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, UK. slowther@sghms.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism* Adolescent Adult Aged Antidepressive Agents / administration & dosage Brain / drug effects, physiology Cadaver Depression / drug therapy, enzymology*, pathology Female Forskolin / pharmacology* Guanosine 5'-O-(3-Thiotriphosphate) / pharmacology* Humans Male Middle Aged Signal Transduction / physiology Suicide* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 37589-80-3/Guanosine 5'-O-(3-Thiotriphosphate); 66428-89-5/Forskolin; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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