| GSK3β genetic variability in patients with Multiple Sclerosis. | |
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MedLine Citation:
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PMID: 21527318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycogen synthase kinase-3 beta (GSK3β) is a ubiquitous kinase that is part of multiple signaling pathways. It has neurotrophic/neuroprotective effects by mediating the actions of neurotrophic molecules in the brain, thus providing neuroprotection through modulation of energy metabolism. Notably, it has been demonstrated that GSK3β is involved in Wnt-beta-catenin signaling, which contributes to the inhibition of myelination and remyelination processes in mammals. Three-hundred nineteen patients with MS and 294 age-matched controls were genotyped by allelic discrimination for four common GSK3β variants (rs2199503, rs9826659, rs334558 and rs6438552) tagging about 100% of GSK-3β variability. A statistically significant increased frequency of the rs334558 GG genotype was observed in patients as compared with controls (25.4% versus 17.7%, P=0.02; OR:1.58, 95%CI: 1.07-2.34). Stratifying MS patients according to the disease subtype, a statistically significant difference of rs334558 GG frequency was found between Relapsing Remitting (RR), but not Primary Progressive or Secondary MS, and controls (27.0% versus 17.7%, P=0.01; OR: 1.72, 95%CI: 1.13-2.61). GSK3β rs334558 is a susceptibility factor for MS. As it is located in the promoter region, a possible explanatory mechanism could be an influence of the variant on the gene transcription rate. |
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Authors:
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Daniela Galimberti; James Macmurray; Diego Scalabrini; Chiara Fenoglio; Milena De Riz; Cristoforo Comi; David Comings; Francesca Cortini; Chiara Villa; Maria Serpente; Claudia Cantoni; Elisa Ridolfi; Ma-Hin Fardipoor; Maurizio Leone; Francesco Monaco; Nereo Bresolin; Elio Scarpini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-17 |
Journal Detail:
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Title: Neuroscience letters Volume: 497 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-10-31 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 46-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy. daniela.galimberti@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Genetic Predisposition to Disease* Genotype Glycogen Synthase Kinase 3 / genetics* Humans Male Middle Aged Multiple Sclerosis / genetics* Polymorphism, Single Nucleotide |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.1/glycogen synthase kinase 3 beta; EC 2.7.11.26/Glycogen Synthase Kinase 3 |
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