Document Detail


GPR56 is essential for testis development and male fertility in mice.
MedLine Citation:
PMID:  20981830     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Testis development is critical for male fertility and continuation of the mammalian species. Essential structural components of testes are seminiferous tubules, which are lined by Sertoli cells and provide nutrients and physical protection for the maturation of sperm. Seminiferous tubule formation is initiated in embryos as testis cords and relies on their remodeling for maturation during development. Recently, three-dimensional image analyses showed that testis cords in different parts of embryonic gonads undergo distinct remodeling processes. How this asymmetric remodeling is regulated has not been investigated. We report here that the absence of an adhesion G protein-coupled receptor, GPR56, leads to partial disruption of seminiferous tubules and reduced fertility in male mice. The defects appear to originate asymmetrically in embryonic gonads, but subsequent to the initial establishment of testis cords, suggesting that GPR56 might act to establish a spatial and/or temporal cue for asymmetric cord remodeling during male gonad development.
Authors:
Guangchun Chen; Liquan Yang; Shahinoor Begum; Lei Xu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-15     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3358-67     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Fertility / genetics,  physiology*
Immunoblotting
Immunohistochemistry
In Situ Hybridization
Male
Mice
Mice, Mutant Strains
Receptors, G-Protein-Coupled / genetics,  metabolism*
Seminiferous Tubules / cytology,  metabolism
Sertoli Cells / cytology,  metabolism
Testis / cytology,  metabolism*
Grant Support
ID/Acronym/Agency:
U54 CA126515/CA/NCI NIH HHS; U54 CA126515-05/CA/NCI NIH HHS; U54-CA126515/CA/NCI NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/GPR56 protein, mouse; 0/Receptors, G-Protein-Coupled
Comments/Corrections

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