| GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. | |
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MedLine Citation:
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PMID: 20813258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omega-3 fatty acids (omega-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor. Stimulation of GPR120 with omega-3 FAs or a chemical agonist causes broad anti-inflammatory effects in monocytic RAW 264.7 cells and in primary intraperitoneal macrophages. All of these effects are abrogated by GPR120 knockdown. Since chronic macrophage-mediated tissue inflammation is a key mechanism for insulin resistance in obesity, we fed obese WT and GPR120 knockout mice a high-fat diet with or without omega-3 FA supplementation. The omega-3 FA treatment inhibited inflammation and enhanced systemic insulin sensitivity in WT mice, but was without effect in GPR120 knockout mice. In conclusion, GPR120 is a functional omega-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation. |
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Authors:
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Da Young Oh; Saswata Talukdar; Eun Ju Bae; Takeshi Imamura; Hidetaka Morinaga; WuQiang Fan; Pingping Li; Wendell J Lu; Steven M Watkins; Jerrold M Olefsky |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Cell Volume: 142 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-09-20 Revised Date: 2012-04-30 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 687-98 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Animals Anti-Inflammatory Agents / administration & dosage, metabolism Cell Line Dietary Fats / metabolism Dietary Supplements Fatty Acids, Omega-3 / administration & dosage*, metabolism* Humans Hypoglycemic Agents / administration & dosage, metabolism Insulin Resistance* Macrophages / immunology Mice Mice, Knockout Obesity / complications Receptors, G-Protein-Coupled / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK 074868/DK/NIDDK NIH HHS; DK033651/DK/NIDDK NIH HHS; DK063491/DK/NIDDK NIH HHS; P01 DK074868-02/DK/NIDDK NIH HHS; P01 DK074868-05/DK/NIDDK NIH HHS; P30 DK063491/DK/NIDDK NIH HHS; P30 DK063491-07/DK/NIDDK NIH HHS; R01 DK033651-29/DK/NIDDK NIH HHS; R37 DK033651/DK/NIDDK NIH HHS; R37 DK033651-26/DK/NIDDK NIH HHS; R37 DK033651-27/DK/NIDDK NIH HHS; U54 HD 012303-25/HD/NICHD NIH HHS; U54 HD012303-25A1/HD/NICHD NIH HHS; U54 HD012303-28/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Hypoglycemic Agents; 0/O3far1 protein, mouse; 0/Receptors, G-Protein-Coupled |
| Comments/Corrections | |
Comment In:
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Cell. 2010 Sep 3;142(5):672-4
[PMID:
20813253
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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