Document Detail

GPIIbIIIa inhibitors as adjunctive therapy in acute myocardial infarction.
MedLine Citation:
PMID:  10402105     Owner:  NLM     Status:  MEDLINE    
Thrombolytic therapy has proved useful in the treatment of acute myocardial infarction but is frequently associated with limited vessel reperfusion and early reocclusion. Local platelet aggregation and activation play a role in these pathological processes, explaining the benefit of aspirin, a weak antiplatelet agent. Recent interest has turned to GPIIbIIIa antagonists, a class of potent inhibitors of platelet aggregation. Their concomitant use with fibrinolytics, in rescue and primary angioplasty for acute myocardial infarction treatment is explored. Efficacy and safety issues are addressed and the potential pivotal role of these agents in the treatment of acute myocardial infarction is discussed.
M Salame; S Verheye; R More; S B King; N Chronos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of cardiology     Volume:  69     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-12     Completed Date:  1999-08-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
Andreas Gruentzig Cardiovascular Center, Division of Cardiology, Emory University, Atlanta, GA 30322, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Drug Therapy, Combination
Myocardial Infarction / drug therapy*,  therapy
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
Randomized Controlled Trials as Topic
Thrombolytic Therapy*
Treatment Outcome
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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