Document Detail


GOAT: the master switch for the ghrelin system?
MedLine Citation:
PMID:  20421334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ghrelin-ghrelin receptor system is one of the most important mechanisms regulating energy balance and metabolism. Among other actions, central and peripheral administration of ghrelin increases food intake and adiposity. During the last years, many efforts have been made in the investigation of the cellular and molecular mechanisms modulating the effects of ghrelin. One particularity of this peptide hormone is its acylation at serine-3 with an eight-carbon fatty acid (octanoate), which confers its biological activity. Recent reports have demonstrated that the ghrelin O-acyltransferase (GOAT) is the enzyme that catalyzes ghrelin octanoylation. Therefore, all questions concerning the posttranslational acylation of ghrelin are of great interest for the complete understanding of this system. In this review, we summarize the discovery and characterization of GOAT, and remark the importance of GOAT as a novel and potential target that regulates the biological actions of ghrelin, revealing several therapeutical possibilities for the treatment of the metabolic syndrome.
Authors:
Amparo Romero; Henriette Kirchner; Kristy Heppner; Paul T Pfluger; Matthias H Tschöp; Ruben Nogueiras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-26
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  163     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-24     Completed Date:  2010-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruña 15782, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acylation
Acyltransferases / genetics,  metabolism*
Animals
Ghrelin / metabolism*
Humans
Models, Biological
Chemical
Reg. No./Substance:
0/Ghrelin; EC 2.3.-/Acyltransferases; EC 2.3.-/ghrelin O-acyltransferase, human

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