| GNAq Mutations are Not Identified in Papillary Thyroid Carcinomas and Hyperfunctioning Thyroid Nodules. | |
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MedLine Citation:
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PMID: 20714830 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Activating mutations of GNAq protein in a hotspot at codon 209 have been recently described in uveal melanomas. Since these neoplasms share with thyroid carcinomas a high frequency of MAP kinase pathway-activating mutations, we hypothesized whether GNAq mutations could also play a role in the development of thyroid carcinomas. Additionally, activating mutations of another subtype of G protein (GNAS1) are frequently found in hyperfunctioning thyroid adenomas, making it plausible that GNAq-activating mutations could also be found in some of these nodules. To investigate thyroid papillary carcinomas and thyroid hyperfuncioning nodules for GNAq mutations in exon 5, codon 209, a total of 32 RET/PTC, BRAF, and RAS negative thyroid papillary carcinomas and 13 hyperfunctioning thyroid nodules were evaluated. No mutations were identified. Although plausible, GNAq mutations seem not to play an important role in the development of thyroid follicular neoplasms, either benign hyperfunctioning nodules or malignant papillary carcinomas. Our results are in accordance with the literature, in which no GNAq hotspot mutations were found in thyroid papillary carcinomas, as well as in an extensive panel of other tumors. The molecular basis for MAP-kinase pathway activation in RET-PTC/BRAF/RAS negative thyroid carcinomas remains to be determined. |
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Authors:
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Clarissa A Cassol; Miao Guo; Shereen Ezzat; Sylvia L Asa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine pathology Volume: 21 ISSN: 1559-0097 ISO Abbreviation: Endocr. Pathol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009288 Medline TA: Endocr Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 250-2 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Toronto, Toronto, ON, Canada, clarissa.cassol@uhnres.utoronto.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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