|GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosis.|
|PMID: 21206329 Owner: NLM Status: MEDLINE|
|OBJECTIVES: GLUT-1 has been found to have an important role in the upregulation of various cellular pathways and implicated in neoplastic transformation correlating with biological behavior in malignancies. However, literature regarding the significance of GLUT-1 expression in pancreatic neoplasia has been limited and controversial.
METHODS: Immunohistochemical expression of GLUT-1 was tested in a variety of pancreatic neoplasia including ductal adenocarcinomas (DAs), pancreatic intraepithelial neoplasms (PanINs), intraductal papillary mucinous neoplasms (IPMNs), and serous cystadenomas.
RESULTS: There was a progressive increase in the expression of GLUT-1 from low- to higher-grade dysplastic lesions: All higher-grade PanINs/IPMNs (the ones with moderate/high-grade dysplasia) revealed noticeable GLUT-1 expression. Among the 94 DAs analyzed, there were minimal/moderate expression in 46 and significant expression in 24 DAs. However, all 4 clear-cell variants of DAs revealed significant GLUT-1 immunolabeling, as did areas of clear-cell change seen in other DAs. Moreover, all 12 serous cystadenomas expressed significant GLUT-1. GLUT-1 expression was also directly correlated with DA histological grade (P = 0.016) and tumor size (P = 0.03).
CONCLUSIONS: GLUT-1 may give rise to the distinctive clear-cell appearance of these tumors by inducing the accumulation of glycogen in the cytoplasm. Additionally, because GLUT-1 expression was related to histological grade and tumor size of DA, further studies are warranted to investigate the association of GLUT-1 with prognosis and tumor progression.
|Olca Basturk; Rajendra Singh; Ecmel Kaygusuz; Serdar Balci; Nevra Dursun; Nil Culhaci; N Volkan Adsay|
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|Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't|
|Title: Pancreas Volume: 40 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2011 Mar|
|Created Date: 2011-02-11 Completed Date: 2011-08-17 Revised Date: 2014-01-01|
Medline Journal Info:
|Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States|
|Languages: eng Pagination: 187-92 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Carcinoma in Situ
Carcinoma, Pancreatic Ductal / chemistry
Carcinoma, Papillary / chemistry
Cystadenoma, Serous / chemistry
Glucose Transporter Type 1 / analysis*
Neoplasms, Cystic, Mucinous, and Serous / chemistry
Pancreatic Neoplasms / chemistry*, diagnosis, mortality, pathology, therapy
Predictive Value of Tests
Proportional Hazards Models
Tumor Markers, Biological / analysis*
|CA101936/CA/NCI NIH HHS; P20 CA101936/CA/NCI NIH HHS; P20 CA101936-05/CA/NCI NIH HHS|
|0/Glucose Transporter Type 1; 0/SLC2A1 protein, human; 0/Tumor Markers, Biological|
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