| GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosis. | |
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MedLine Citation:
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PMID: 21206329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: GLUT-1 has been found to have an important role in the upregulation of various cellular pathways and implicated in neoplastic transformation correlating with biological behavior in malignancies. However, literature regarding the significance of GLUT-1 expression in pancreatic neoplasia has been limited and controversial. METHODS: Immunohistochemical expression of GLUT-1 was tested in a variety of pancreatic neoplasia including ductal adenocarcinomas (DAs), pancreatic intraepithelial neoplasms (PanINs), intraductal papillary mucinous neoplasms (IPMNs), and serous cystadenomas. RESULTS: There was a progressive increase in the expression of GLUT-1 from low- to higher-grade dysplastic lesions: All higher-grade PanINs/IPMNs (the ones with moderate/high-grade dysplasia) revealed noticeable GLUT-1 expression. Among the 94 DAs analyzed, there were minimal/moderate expression in 46 and significant expression in 24 DAs. However, all 4 clear-cell variants of DAs revealed significant GLUT-1 immunolabeling, as did areas of clear-cell change seen in other DAs. Moreover, all 12 serous cystadenomas expressed significant GLUT-1. GLUT-1 expression was also directly correlated with DA histological grade (P = 0.016) and tumor size (P = 0.03). CONCLUSIONS: GLUT-1 may give rise to the distinctive clear-cell appearance of these tumors by inducing the accumulation of glycogen in the cytoplasm. Additionally, because GLUT-1 expression was related to histological grade and tumor size of DA, further studies are warranted to investigate the association of GLUT-1 with prognosis and tumor progression. |
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Authors:
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Olca Basturk; Rajendra Singh; Ecmel Kaygusuz; Serdar Balci; Nevra Dursun; Nil Culhaci; N Volkan Adsay |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 40 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-11 Completed Date: 2011-08-17 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Affiliation:
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Department of Pathology, New York University, New York, NY, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma in Situ
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chemistry Carcinoma, Pancreatic Ductal / chemistry Carcinoma, Papillary / chemistry Chi-Square Distribution Cystadenoma, Serous / chemistry Glucose Transporter Type 1 / analysis* Humans Immunohistochemistry Kaplan-Meier Estimate Neoplasm Invasiveness Neoplasm Staging Neoplasms, Cystic, Mucinous, and Serous / chemistry Pancreatic Neoplasms / chemistry*, diagnosis, mortality, pathology, therapy Predictive Value of Tests Prognosis Proportional Hazards Models Risk Assessment Risk Factors Tumor Markers, Biological / analysis* Turkey United States Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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CA101936/CA/NCI NIH HHS; P20 CA101936-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucose Transporter Type 1; 0/SLC2A1 protein, human; 0/Tumor Markers, Biological |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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