Document Detail


GLP-1 and cardiac cell survival.
MedLine Citation:
PMID:  23031433     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
During myocardial infarction (MI), a variety of mechanisms contribute to activation of cell death processes in cardiomyocytes, which determines the final MI size, subsequent mortality, and post-MI remodeling. The deleterious mechanisms activated during the ischemia and reperfusion phases in MI include oxygen deprival, decreased availability of nutrients and survival factors, accumulation of waste products, generation of oxygen free radicals, calcium overload, neutrophil infiltration in the ischemic area, depletion of energy stores, and opening of the mitochondrial permeability transition pore, all of them contributing to activation of apoptosis and necrosis in cardiomyocytes. Glucagon-like peptide-1 [GLP-1 (7-36) amide] has gained relevance in recent years for metabolic treatment of patients with type 2 diabetes mellitus. Cytoprotection of different cell types, including cardiomyocytes, is among the pleiotropic actions reported for GLP-1. This paper reviews the most relevant experimental studies that have contributed to a better understanding of the molecular mechanisms and intracellular pathways involved in cardioprotection induced by GLP-1 and analyzes in depth its potential role as a therapeutic target both in the ischemic and reperfused myocardium and in other conditions that are associated with myocardial remodeling and heart failure.
Authors:
Susana Ravassa; Amaia Zudaire; Javier Díez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-29
Journal Detail:
Title:  Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion     Volume:  -     ISSN:  1579-2021     ISO Abbreviation:  Endocrinol Nutr     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886482     Medline TA:  Endocrinol Nutr     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 SEEN. Published by Elsevier Espana. All rights reserved.
Affiliation:
Área de Ciencias Cardiovasculares, Centro para la Investigación Médica Aplicada, Universidad de Navarra, Pamplona, España. Electronic address: sravassa@unav.es.
Vernacular Title:
Péptido similar al glucagón tipo 1 y supervivencia de la célula cardiaca.
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