Document Detail

The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes?
MedLine Citation:
PMID:  18640239     Owner:  NLM     Status:  MEDLINE    
Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of type 2 diabetes (T2D) mellitus. Nowadays, the debate focuses on the possible mechanisms responsible for abnormal islet microenvironment, decreased beta-cell number, impaired beta-cell function, and their multifactorial aetiologies. This review is aimed to illustrate to what extend the Goto-Kakizaki rat, one of the best characterized animal models of spontaneous T2D, has proved be a valuable tool offering sufficient commonalities to study these aspects. We propose that the defective beta-cell mass and function in the GK model reflect the complex interactions of multiple pathogenic players: (i) several independent loci containing genes responsible for some diabetic traits (but not decreased beta-cell mass); (ii) gestational metabolic impairment inducing an epigenetic programming of the pancreas (decreased beta-cell neogenesis and/or proliferation) which is transmitted to the next generation; and (iii) loss of beta-cell differentiation due to chronic exposure to hyperglycemia/hyperlipidemia, inflammatory mediators, oxidative stress and to perturbed islet microarchitecture.
B Portha; G Lacraz; M Kergoat; F Homo-Delarche; M-H Giroix; D Bailbé; M-N Gangnerau; M Dolz; C Tourrel-Cuzin; J Movassat
Related Documents :
15125899 - Engineering a new beta-cell: a critical venture requiring special attention to constant...
3159609 - Chlorozocin. a diabetogenic analogue of streptozocin with dissimilar mechanisms of acti...
19729529 - Beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regul...
10629049 - Mutations in host cell factor 1 separate its role in cell proliferation from recruitmen...
7776969 - C-fos protooncogene is involved in the mitogenic effect of transforming growth factor-b...
16025399 - Quantitative evaluation of a monoclonal antibody and its fragment as potential markers ...
16685409 - Method for efficient transfection of in vitro-transcribed mrna into sk-n-as and hek293 ...
17586459 - Multi-photon microscopic imaging of rat parotid ducts demonstrates cellular heterogenei...
8256559 - An improved sedimentation technique for the cytologic preparation of cerebrospinal flui...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-07-01
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  297     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  73-85     Citation Subset:  IM    
Groupe Biologie et Pathologie du Pancréas Endocrine, Laboratoire de Physiopathologie de la Nutrition, UMR CNRS 7059, Université Paris-Diderot/UP7, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diabetes Mellitus, Type 2 / pathology*,  physiopathology
Disease Models, Animal
Insulin-Secreting Cells / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Decreased expression of the IGF-II gene during porcine adipose cell differentiation.
Next Document:  Both MHC and non-MHC genes regulate development of experimental neuropathic pain in rats.