| GIP: no longer the neglected incretin twin? | |
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MedLine Citation:
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PMID: 20844284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the design of therapeutics to treat type 2 diabetes, researchers have exploited the observation that oral ingestion of nutrients leads to the secretion of glucose homeostasis-regulating incretin hormones (for example, glucagon-like-peptide-1) from the gut. Here, we discuss two recent papers that suggest that the "other" incretin hormone, gastric inhibitory polypeptide (GIP), also is important in the regulation of glucose homeostasis. These findings warrant further studies to unravel the mechanism of action of GIP in β-cells of the endocrine pancreas and to evaluate the possibility of designing novel therapeutics that target both incretin hormones. |
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Authors:
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Rohit N Kulkarni |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science translational medicine Volume: 2 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2010-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
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Languages: eng Pagination: 49ps47 Citation Subset: IM |
Affiliation:
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Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Rohit.Kulkarni@joslin.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose Diabetes Mellitus, Type 2 / blood, metabolism* Gastric Inhibitory Polypeptide / metabolism* Glucagon-Like Peptide 1 / metabolism Humans Incretins / metabolism* Insulin-Secreting Cells / metabolism Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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DK R01 67536/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Incretins; 59392-49-3/Gastric Inhibitory Polypeptide; 89750-14-1/Glucagon-Like Peptide 1 |
| Comments/Corrections | |
Erratum In:
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Sci Transl Med. 2010 Sep 22;2(50):50er2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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