Document Detail


GH Responses to 2 Consecutive Bouts of Respiratory Muscle Endurance Training in Obese Adolescents and Adults.
MedLine Citation:
PMID:  23700319     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Repeated bouts of GH-releasing stimuli (both pharmacological and physiological, such as aerobic exercise) at 2-h intervals are associated with a blunting of somatotropic responsiveness in normal adults, while a persistent GH responsiveness to consecutive stimuli is reported to occur in children and adolescents. Recently, a single bout of respiratory muscle endurance training (RMET) by means of a specific commercially available device (Spiro Tiger®) has been shown to induce relevant GH responses in both normal-weighted and obese adult subjects. The aim of the present study was to evaluate GH responses to repeated bouts of RMET in obese adolescents and adults. Seven obese male adolescents (age: 15.7±0.4 years; body mass index, BMI: 38.0±3.3 kg/m2) and 10 obese adults (age: 22.2±1.4 years; BMI: 39.9±1.0 kg/m2) underwent an incremental progressive RMET protocol of 11 daily sessions. Blood samplings for GH determinations were collected during the 12th session, which was composed of 2 consecutive bouts of RMET (of identical intensity and duration: 1 min at a respiration rate of 28 acts/min, 5 min at 32 acts/min, 5 min at 34 acts/min, 4 min at 36 acts/min) at a 2-h interval in-between. Baseline GH levels significantly increased after the first bout of RMET in all subjects, higher GH peaks being found in obese adults than in obese adolescents (peaks: 14.3±2.1 ng/ml vs. 4.8±1.6 ng/ml, respectively, p<0.05). The administration of the second bout of RMET resulted in significantly lower (p<0.05) GH increases in both obese adolescents and obese adults (peaks: 0.9±0.2 ng/ml and 1.6±0.2 ng/ml, respectively) in comparison with the first one. In conclusion, exercise protocols based on repeated bouts of RMET do not seem a valid strategy to persistently stimulate GH-IGF-1 release in obese adolescents, since GH responses to a single bout are actually modest in comparison with those of obese adults and completely abolished after repeated bouts at 2 h interval in-between.
Authors:
A Sartorio; F Agosti; A Patrizi; G Tringali; S G Cella; A E Rigamonti
Related Documents :
10069389 - Application of metabolic control analysis to the study of toxic effects of copper in mu...
15186919 - Energy transfer from astrocytes to axons: the role of cns glycogen.
7882189 - Preservation of sarcoplasmic reticulum ca2(+)-sequestering function in homogenates of d...
3132449 - Muscle glycogen synthesis after exercise: effect of time of carbohydrate ingestion.
1542049 - Carbohydrate supplementation during exercise.
9575949 - Effects of increased fat availability on fat-carbohydrate interaction during prolonged ...
24714059 - 12-mo intervention of physical exercise improved work ability, especially in subjects w...
25381979 - Self-reported adherence to a home-based exercise program among patients affected by pso...
22939039 - Hemodynamic determinants of the abnormal cardiopulmonary exercise response in heart fai...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-22
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme     Volume:  -     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Verbania, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Typical urban gully nitrogen migration in Changchun City, China.
Next Document:  The Effect of Leptin Administration on Mammary Tumor Growth in Diabetic Mice.