Document Detail

GH Replacement Improves Quality of Life and Metabolic Parameters in Cured Acromegalic Patients with Growth Hormone Deficiency.
MedLine Citation:
PMID:  22904173     Owner:  NLM     Status:  Publisher    
Objective:Effects of GH replacement in patients with GH deficiency (GHD) after a cure for acromegaly so far have been poorly studied, although its prevalence among acromegalic patients may reach the 60%. The aim of the study was to evaluate whether metabolic parameters and quality of life are improved by GH replacement in patients with prior acromegaly and severe GHD.Design and Methods:This was a prospective study on 42 GHD subjects [22 men, mean age (sd): 48 ± 10]: 10 acromegalics treated with recombinant human GH (group A), 12 acromegalics who refused treatment (group B), and 20 subjects operated for nonfunctioning pituitary adenoma on recombinant human GH (group C). Serum IGF-I levels, lipid profile, glucose levels (fasting and after an oral glucose tolerance test), glycosylated hemoglobin, insulin resistance (homeostasis model assessment insulin resistance index), anthropometric parameters (body mass index, waist circumference, body composition), and quality of life (Questions on Life Satisfaction-Hypopituitarism Z-scores) were evaluated at baseline and after 12 and 36 months.Results:At baseline, group B showed higher IGF sd score than group A and C, as well as better quality of life and higher post-oral glucose tolerance test glucose levels than group A. After 12-months, similarly in group A and C, the IGF-I sd score significantly increased, and body composition and lipid profile improved, without deterioration of glucose tolerance. Quality of life significantly improved too, and the baseline difference between group A and B disappeared. Results were confirmed after 36 months.Conclusions:In GHD acromegalic patients, GH therapy improved body composition, lipid profile, and quality of life as in patients with GHD due to nonfunctioning pituitary adenoma, without negative effects on glucose metabolism. GH replacement therapy should be considered in these patients, as in patients with GHD from other causes.
Claudia Giavoli; Eriselda Profka; Elisa Verrua; Cristina L Ronchi; Emanuele Ferrante; Silvia Bergamaschi; Elisa Sala; Elena Malchiodi; Andrea G Lania; Maura Arosio; Bruno Ambrosi; Anna Spada; Paolo Beck-Peccoz
Related Documents :
17507823 - Effects of controlled perioperative antimicrobial prophylaxis on infectious outcomes in...
8036463 - Topical metronidazole treatment in pouchitis.
21928403 - Late results of endoscopic thoracic sympathectomy for hyperhidrosis and facial blushing.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-17
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Clinical Sciences and Community Health (C.G., E.P., E.V., E.F., S.B., E.S., E.M., M.A., A.S., P.B.-P.), University of Milan, Endocrinology and Diabetology Unit (C.G., E.P., E.V., E.F., S.B., E.S., E.M., A.S., P.B.-P.), Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; University Hospital (C.L.R.), 97080 Wuerzburg, Germany; BIOMETRA Department (A.G.L.), University of Milan and Endocrine Unit, Humanitas Cinical and Research Center, Rozzano, 20089 Milan, Italy; Unit of Endocrine Diseases (M.A.), Ospedale S. Giuseppe Multimedica, 20123 Milan, Italy; and Department of Medical and Surgical Sciences (B.A.), University of Milan, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, 20097 San Donato Milanese, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genome-wide copy number variation association analyses for age at menarche.
Next Document:  Inflammation in response to glucose ingestion is independent of excess abdominal adiposity in normal...