Document Detail


GH and PRL-Producing Pituitary Adenoma with Neuron-Like Differentiation.
MedLine Citation:
PMID:  12114774     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A pituitary adenoma with neuron-like differentiation in the sella turcica is reported. Sections of the tumor showed a mixture of adenoma cells, ganglionic cells, and neuropil-like structures by light microscopy. Both pituitary adenoma cells and large cells recognized as ganglionic cells by H&E were strongly immunoreactive for both growth hormone (GH) and prolactin (PRL), which indicated that these large cells had properties similar to those of pituitary adenoma cells. Furthermore, electron microscopy (EM) revealed characteristic low electron-dense secretory granules as well as GH-type large electron-dense secretory granules in adenoma cells, neuropils, and swollen bulbs of neuronal endings, which indicated that these three populations may be of the same origin. Furthermore, we could not find typical cell bodies of ganglionic cells by EM. These results are consistent with a hypothesis that attempts to explain the origin of the neuronal components by the neuronal differentiation of adenoma cells. Thus, the best designation of our tumor may be "pituitary adenoma with neuron-like differentiation."
Authors:
Ikuo Kobayashi; Toru Kameya; Hidehiro Oka; Heiji Naritaka; Nobuyuki Kawano; Kiyotaka Fujii
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Endocrine pathology     Volume:  10     ISSN:  1559-0097     ISO Abbreviation:  Endocr. Pathol.     Publication Date:  1999  
Date Detail:
Created Date:  2002-Jul-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009288     Medline TA:  Endocr Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  367-374     Citation Subset:  -    
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