Document Detail

GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice.
MedLine Citation:
PMID:  23209615     Owner:  NLM     Status:  MEDLINE    
Here we demonstrate, both in vivo and in vitro, that growth hormone (GH) mediates precursor cell activation in the subventricular zone (SVZ) of the aged (12-month-old) brain following exercise, and that GH signaling stimulates precursor activation to a similar extent to exercise. Our results reveal that both addition of GH in culture and direct intracerebroventricular infusion of GH stimulate neural precursor cells in the aged brain. In contrast, no increase in neurosphere numbers was observed in GH receptor null animals following exercise. Continuous infusion of a GH antagonist into the lateral ventricle of wild-type animals completely abolished the exercise-induced increase in neural precursor cell number. Given that the aged brain does not recover well after injury, we investigated the direct effect of exercise and GH on neural precursor cell activation following irradiation. This revealed that physical exercise as well as infusion of GH promoted repopulation of neural precursor cells in irradiated aged animals. Conversely, infusion of a GH antagonist during exercise prevented recovery of precursor cells in the SVZ following irradiation.
Daniel G Blackmore; Jana Vukovic; Michael J Waters; Perry F Bartlett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-27
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-06-11     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e49912     Citation Subset:  IM    
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
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MeSH Terms
Age Factors
Dentate Gyrus / drug effects,  metabolism*,  radiation effects
Growth Hormone / administration & dosage,  metabolism*,  pharmacology
Lateral Ventricles / drug effects,  metabolism*,  radiation effects
Mice, Knockout
Neural Stem Cells / drug effects,  metabolism*
Physical Conditioning, Animal*
Receptors, Somatotropin / genetics,  metabolism
Reg. No./Substance:
0/Receptors, Somatotropin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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