Document Detail

GH Deficiency in Adult B-Thalassemia Major Patients and Its Relationship with IGF-1 Production.
MedLine Citation:
PMID:  21705979     Owner:  NLM     Status:  In-Data-Review    
Endocrine complications in Β-thalassemia represent a prominent cause of morbidity. Above all, dysfunction of GH-IGF-1 axis is of a major concern because of its pathogenic role on cardiac and bone disease, frequently described in this clinical setting. The aim of this paper is to analyze GH-IGF-1 axis in a cohort of 25 adult patients affected by Β-thalassemia. We found that GH deficiency was present in only 8% of our patients if diagnosis was based on GH peak below 9μg/L to two GH provocative tests instead of only one, and was mainly related to iron overload. On the contrary, IGF-1 production was impaired in a higher percentage of patients (72%), without significant correlation with iron burden. Of note, patients with hepatitis C virus infection showed lower IGF-1 concentrations than uninfected subjects despite a normal GH reserve, suggesting that partial GH insensitivity at the post-receptor level may play a key role in IGF-1 deficiency described in thalassemic patients.
Angela Ida Pincelli; Nicoletta Masera; Luisa Tavecchia; Mario Perotti; Silvia Perra; Raffaela Mariani; Alberto Piperno; Giuseppe Mancia; Guido Grassi; Giuseppe Masera
Related Documents :
18205769 - Barrett's esophagus: a retrospective analysis of 13 years surveillance.
20456759 - Increased trpv1 gene expression in esophageal mucosa of patients with non-erosive and e...
21611719 - Chronic treatment of paroxysmal nocturnal hemoglobinuria patients with eculizumab: safe...
14572559 - Prevalence of esophageal candidiasis among patients treated with inhaled fluticasone pr...
1954529 - Radiological assessment of dysphagia in parkinson's disease.
3497189 - Esophageal perforation after fiberoptic variceal sclerotherapy.
11245029 - Outpatient diagnostic hysteroscopy: analysis of 429 cases.
22788929 - Efficacy of transient elastography in screening for large esophageal varices in patient...
8604709 - Electron beam computed tomography in the evaluation of cardiac calcification in chronic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric endocrinology reviews : PER     Volume:  8 Suppl 2     ISSN:  1565-4753     ISO Abbreviation:  Pediatr Endocrinol Rev     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101202124     Medline TA:  Pediatr Endocrinol Rev     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  IM    
Clinica Medica, Universitá Milano-Bicocca, Ospedale San Gerardo dei Tintori Via Pergolesi 33, 20052 Monza, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Age related igf-I changes and igf-I generation in thalassemia major.
Next Document:  Growth Hormone and Adrenal Response to Intramuscular Glucagon Test and Its Relationship to IGF-1 Pro...