| GFR estimated from cystatin C versus creatinine in children born small for gestational age. | |
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MedLine Citation:
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PMID: 18455848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Low birth weight caused by intrauterine growth restriction may be a risk factor for renal impairment in the adult life. STUDY DESIGN: A cross-sectional study. SETTING & PARTICIPANTS: 71 children aged 8 to 13 years living in the community of São Paulo, Brazil, were included in the study. Gestational age was within the normal range. PREDICTORS: Birth weight (range, 2,052 to 3,560 g) divided into quartiles: 2,500 g or less; 2,501 to 2,740 g; 2,741 to 3,000 g; and greater than 3,000 g. Birth weight ascertained by birth records in 43 and by recall in 28 participants. OUTCOMES & MEASUREMENTS: Cystatin C, creatinine, and glomerular filtration rate (GFR) estimated by equations using cystatin C (eGFR(cys)) or creatinine (eGFR(cr)). RESULTS: Overall, mean serum creatinine level was 0.8 +/- 0.01 (SE) mg/dL (range, 0.7 to 1.1 mg/dL); mean plasma cystatin C level was 0.9 +/- 0.02 mg/L (range, 0.5 to 1.6 mg/L), and eGFR(cr) and eGFR(cys) were 102.4 +/- 2.16 (range, 66 to 140) and 91.8 +/- 2.46 mL/min/1.73 m(2) (range, 49 to 139 mL/min/1.73 m(2)), respectively. No differences were found for serum creatinine or eGFR(cr) values among the birth-weight quartiles. There was a significant linear trend of increasing cystatin C levels (decreasing eGFR(cys)) in the lower birth-weight quartile groups (P = 0.002 and P = 0.02, respectively). Systolic blood pressure correlated with plasma cystatin C level (r = 0.31; P = 0.008) and eGFR(cys) (r = -0.26; P = 0.028). Covariance analysis adjusting for age, sex, body mass index for age compared with standards of the National Center for Health Statistics and expressed as a z score, and systolic blood pressure showed that cystatin C values remained greater in the lowest than highest birth-weight quartile (1.01 +/- 0.05 versus 0.83 +/- 0.05 mg/L; P = 0.02). LIMITATIONS: Ascertainment of birth weight by recall in some participants. Lack of measurement of microalbuminuria, absence of direct GFR measurement, and small sample size. CONCLUSIONS: Lower birth weight is associated with higher levels of cystatin C but not creatinine in 8-13 yr. old children born full-term. |
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Authors:
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Maria C P Franco; Sônia K Nishida; Ricardo Sesso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-02 |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 51 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-07-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 925-32 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil. mdcfranco@nefro.epm.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Creatinine / blood* Cross-Sectional Studies Cystatin C Cystatins / blood* Female Glomerular Filtration Rate* Humans Infant, Newborn Infant, Small for Gestational Age* Male |
| Chemical | |
Reg. No./Substance:
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0/CST3 protein, human; 0/Cystatin C; 0/Cystatins; 60-27-5/Creatinine |
| Comments/Corrections | |
Comment In:
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Am J Kidney Dis. 2008 Oct;52(4):807; author reply 807-8
[PMID:
18805356
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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