| GFR determined by nonradiolabeled iothalamate using capillary electrophoresis. | |
| | |
MedLine Citation:
|
PMID: 9370179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Traditional measurements of glomerular filtration rate (GFR) in clinical practice include the measurement of serum creatinine or creatinine clearance. Increasing evidence concerning the limitation of these measurements in clinical practice and clinical trials has resulted in efforts to develop technologies that improve measurement of GFR. Recent efforts in that regard have used radioisotopic labeling of markers of GFR, such as 125I-iothalamate, and 51Cr-ethylenediaminetetraacetic acid. Limitations of these technologies include radiation exposure as well as cost considerations for the management of radioisotopes, including safety, disposal, mailing, and deteriorating activity that results in short shelf life. We report a test that used 0.5 mL Conray dye injected subcutaneously and subsequent measurement of the nonisotopic (cold) iothalamate by capillary electrophoresis in blood and urine. GFR using cold iothalamate compared with standard clearance using 125I-iothalamate was 0.99. The method is cost-effective and allows for avoiding exposure to isotopes, as well as problems such as the disposal and short shelf life of isotopes. This technology could allow for replacement of 125I-iothalamate as a marker for GFR. |
| | |
Authors:
|
D M Wilson; J H Bergert; T S Larson; R R Liedtke |
Related Documents
:
|
19413919 - The emperors new clothiers. 21861599 - General practitioners' experiences using cognitive behavioural therapy in general pract... 19072339 - Circumferential and focal radiofrequency ablation for the treatment of barrett's esopha... 16372789 - A span of control tool for clinical managers. 22002779 - Competency in musculoskeletal and sports medicine: evaluating a pgy-1 curriculum. 1594199 - How useful are contrast sensitivity charts in optometric practice? case reports. 19489779 - Antimicrobial use in the australian pig industry: results of a national survey. 22527589 - Preauricular incision outlining during a face-lift: a step-by-step description. 3558079 - Effects of nonadherent dressing materials on the healing of open wounds in dogs. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 30 ISSN: 0272-6386 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1997 Nov |
Date Detail:
|
Created Date: 1997-12-05 Completed Date: 1997-12-05 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 646-52 Citation Subset: IM |
Affiliation:
|
Division of Nephrology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Contrast Media* / administration & dosage, economics Cost-Benefit Analysis Drug Interactions Electrophoresis, Capillary / economics, methods, statistics & numerical data Evaluation Studies as Topic Glomerular Filtration Rate* Humans Iodine Radioisotopes / administration & dosage, diagnostic use Iothalamic Acid / administration & dosage, diagnostic use*, economics Kidney Function Tests / economics, methods, statistics & numerical data Middle Aged Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Iodine Radioisotopes; 2276-90-6/Iothalamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A randomized trial comparing cyclosporine induction with sequential therapy in renal transplant reci...
Next Document: Aluminum utensils contribute to aluminum accumulation in patients with renal disease.