Document Detail


GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease.
MedLine Citation:
PMID:  18602179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Outer hair cell (OHC) loss in the auditory sensory epithelium is a primary cause of noise-induced sensory-neural hearing loss (SNHL). To clarify the participation of glial cells in SNHL, we used an Alexander disease (AxD) mouse model. These transgenic mice harbor the AxD causal mutant of the human glial fibrillary acidic protein (GFAP) under the control of the mouse GFAP promoter. It is thought that GFAP aggregates compromise the function of astrocytes. In the auditory pathway, the formation of GFAP aggregates was observed only in GFAP-positive cells of the cochlear nerve. The presence of GFAP aggregates did not change auditory function at the threshold level. To assess the change in vulnerability to auditory excitotoxicity, both transgenic and control mice were treated with intense noise exposure. Auditory threshold shifts were assessed by auditory brainstem responses (ABR) at 1 and 4 weeks after noise exposure, and OHC damage was analyzed by quantitative histology at 4 weeks after exposure. Transgenic mice showed more severe ABR deficits and OHC damage, suggesting that cochlear nerve glial cells with GFAP aggregates play a role in noise susceptibility. Thus, we should focus more on the roles of cochlear nerve glial cells in SNHL.
Authors:
Masatsugu Masuda; Kenji F Tanaka; Sho Kanzaki; Kenichiro Wakabayashi; Naoki Oishi; Takafumi Suzuki; Kazuhiro Ikenaka; Kaoru Ogawa
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Publication Detail:
Type:  Journal Article     Date:  2008-07-03
Journal Detail:
Title:  Neuroscience research     Volume:  62     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  15-24     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Keio University, School of Medicine, Tokyo, Japan. masoeur13@mac.com
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / adverse effects
Alexander Disease / genetics,  metabolism*,  physiopathology
Animals
Astrocytes / metabolism,  pathology
Auditory Threshold / physiology
Cochlear Nerve / metabolism*,  pathology,  physiopathology
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem / physiology
Glial Fibrillary Acidic Protein / genetics,  metabolism*
Hearing Loss, Noise-Induced / metabolism,  pathology,  physiopathology
Hearing Loss, Sensorineural / etiology,  metabolism*,  physiopathology
Inclusion Bodies / genetics,  metabolism,  pathology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Degeneration / genetics,  metabolism,  physiopathology
Neurons, Afferent / metabolism*,  pathology
Noise / adverse effects
Organ of Corti / metabolism*,  pathology,  physiopathology
Chemical
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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