| GCF and serum myeloperoxidase and matrix metalloproteinase-13 levels in renal transplant patients. | |
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MedLine Citation:
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PMID: 20637451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The rationale of this study was to address whether local or systemic changes reflect proteolytic (matrix metalloproteinase-13) or oxidative (myeloperoxidase) stress in renal transplant patients receiving cyclosporine-A (CsA) and having gingival overgrowth (GO), in patients receiving CsA therapy and having no GO and patients receiving tacrolimus therapy. MATERIAL AND METHODS: Gingival crevicular fluid (GCF) samples were collected from sites with (GO+) and without GO (GO-) in CsA patients having GO; GO- sites in CsA patients having no GO; sites from tacrolimus, gingivitis and healthy subjects. GCF and serum myeloperoxidase (MPO) and matrix metalloproteinase-13 (MMP-13) levels were determined by ELISA. RESULTS: GO+ sites in CsA patients having GO had elevated GCF MPO levels than those of CsA patients having no GO, tacrolimus and healthy subjects (p<0.005), but comparable to those of gingivitis. GCF MPO levels were higher in GO+ compared to GO- sites in CsA patients having GO (p<0.05). Patient groups had similar, but higher GCF MMP-13 levels than healthy group. CONCLUSIONS: These results show that CsA and tacrolimus therapy have not a significant effect on GCF MPO and MMP-13 levels, and gingival inflammation seems to be the main reason for their elevations. |
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Authors:
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Gülnur Emingil; Beral Afacan; Taina Tervahartiala; Hüseyin Töz; Gül Atilla; Timo Sorsa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-15 |
Journal Detail:
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Title: Archives of oral biology Volume: 55 ISSN: 1879-1506 ISO Abbreviation: Arch. Oral Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-12-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0116711 Medline TA: Arch Oral Biol Country: England |
Other Details:
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Languages: eng Pagination: 719-27 Citation Subset: D; IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Ege University, School of Dentistry, Department of Periodontology, Bornova, 35100 Izmir, Turkey. gemingil@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Cyclosporine / adverse effects*, blood Enzyme-Linked Immunosorbent Assay Female Gingival Crevicular Fluid / enzymology* Gingival Overgrowth / blood, chemically induced*, enzymology Gingivitis / enzymology* Humans Immunosuppressive Agents / adverse effects*, blood Kidney Transplantation* Male Matrix Metalloproteinase 13 / analysis, blood, metabolism* Middle Aged Normal Distribution Peroxidase / analysis, blood, metabolism* Statistics, Nonparametric Tacrolimus / blood, therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine; EC 1.11.1.7/Peroxidase; EC 3.4.24.-/Matrix Metalloproteinase 13 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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