Document Detail


GC-FID as a primary method for establishing the purity of organic CRMs used for drugs in sport analysis.
MedLine Citation:
PMID:  11451235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The National Analytical Reference Laboratory has synthesized and characterized 67 anabolic steroid marker metabolites, both unlabelled and deuterated, and 37 key glucuronide and sulfate steroid conjugate pure substance reference materials. Work is also in process to establish their full traceability so that they can be issued as certified and primary reference materials. Both identity and purity have been rigorously characterized using a number of techniques and a primary method for purity assessment developed, based gas chromatography combined with flame ionization detection for the parent steroids and HPLC with evaporative light scattering detection for non-volatile steroid conjugates. Strategies for establishing traceability and for estimating measurement uncertainty are reported. The strategies described are considered applicable to a wide range of organic pure substance reference materials.
Authors:
B King; S Westwood
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Fresenius' journal of analytical chemistry     Volume:  370     ISSN:  0937-0633     ISO Abbreviation:  Fresenius J Anal Chem     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-13     Completed Date:  2001-07-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9114077     Medline TA:  Fresenius J Anal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  194-9     Citation Subset:  IM    
Affiliation:
National Analytical Reference Laboratory, Pymble, NSW, Australia. bernard.king@agal.gov.au
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Anabolic Agents / analysis,  standards*
Chromatography, Gas / methods,  standards*
Doping in Sports*
Drug Stability
Epitestosterone / analysis
Humans
Probability
Reference Standards
Substance Abuse Detection / methods,  standards*
Chemical
Reg. No./Substance:
0/Anabolic Agents; 481-30-1/Epitestosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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