| GC-FID as a primary method for establishing the purity of organic CRMs used for drugs in sport analysis. | |
| | |
MedLine Citation:
|
PMID: 11451235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The National Analytical Reference Laboratory has synthesized and characterized 67 anabolic steroid marker metabolites, both unlabelled and deuterated, and 37 key glucuronide and sulfate steroid conjugate pure substance reference materials. Work is also in process to establish their full traceability so that they can be issued as certified and primary reference materials. Both identity and purity have been rigorously characterized using a number of techniques and a primary method for purity assessment developed, based gas chromatography combined with flame ionization detection for the parent steroids and HPLC with evaporative light scattering detection for non-volatile steroid conjugates. Strategies for establishing traceability and for estimating measurement uncertainty are reported. The strategies described are considered applicable to a wide range of organic pure substance reference materials. |
| | |
Authors:
|
B King; S Westwood |
Related Documents
:
|
618675 - A simplified method for the determination of steroids in diets and faeces. 533235 - Improved method for the measurement of pregnanetriol in urine. 7096465 - Sample purification using a c18-bonded reversed-phase cartridge for the quantitative an... 17386695 - A downscaled multi-residue strategy for detection of anabolic steroids in bovine urine ... 21328395 - Analysis of methylene blue and its metabolites in blood by capillary electrophoresis/el... 12125035 - Use of an adsorbed chiral selector in capillary lc-ms. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Fresenius' journal of analytical chemistry Volume: 370 ISSN: 0937-0633 ISO Abbreviation: Fresenius J Anal Chem Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2001-07-13 Completed Date: 2001-07-26 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9114077 Medline TA: Fresenius J Anal Chem Country: Germany |
Other Details:
|
Languages: eng Pagination: 194-9 Citation Subset: IM |
Affiliation:
|
National Analytical Reference Laboratory, Pymble, NSW, Australia. bernard.king@agal.gov.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Anabolic Agents / analysis, standards* Chromatography, Gas / methods, standards* Doping in Sports* Drug Stability Epitestosterone / analysis Humans Probability Reference Standards Substance Abuse Detection / methods, standards* |
| Chemical | |
Reg. No./Substance:
|
0/Anabolic Agents; 481-30-1/Epitestosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Water as a source of errors in reference materials.
Next Document: Reference materials at emission levels of NH3 and HCl.