Document Detail


GB virus C/hepatitis G virus infection in Indian blood donors and high-risk groups.
MedLine Citation:
PMID:  15062748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hepatitis G virus (HGV) or GB virus C (GBV-C) was discovered in 1995 as a putative agent of post-transfusion, non-A-E hepatitis. The present study was carried out with the aim to find the prevalence of this virus among various subject groups at risk for parenteral transmission as well as in healthy control subjects both individually and along with other parenterally transmitted hepatitis viruses. Of the 402 subjects tested, 6.22% were positive for the HBsAg surface antigen, 7.21% were positive for HCV RNA while only 2.24% were seen to be carriers of the HGV/GBV-C RNA. All the HGV/GBV-C positive cases were either multi-transfused thalassaemic subjects or hemodialysis patients. None of the healthy control subjects showed presence of the virus. Seven of the HGV/GBV-C positive subjects showed co-infection with one or more additional virological markers. Also, of the 9 HGV/GBV-C positive subjects, 5 showed elevated ALT levels while 4 showed elevated alkaline phosphatase levels. Overall our findings seem to indicate that HGV infections generally are asymptomatic, transient and self-limiting and the virus does not seem to show a very high prevalence among the Indian population.
Authors:
Mayura M Desai; Ramprasad B Pal; Dushyant D Banker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis     Volume:  30     ISSN:  1473-0502     ISO Abbreviation:  Transfus. Apher. Sci.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-11-19     Revised Date:  2006-06-07    
Medline Journal Info:
Nlm Unique ID:  101095653     Medline TA:  Transfus Apher Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  T    
Affiliation:
Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Sir Hurkisondas Nurrotumdas Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai 400004, India. desaimayura@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Blood Donors*
Child
Child, Preschool
Cohort Studies
DNA, Complementary / metabolism
Female
Flaviviridae Infections / blood,  epidemiology*,  transmission*
GB virus C / metabolism*
Hepacivirus / genetics
Hepatitis B Surface Antigens / chemistry*
Hepatitis, Viral, Human / blood,  epidemiology*,  transmission*
Humans
India
Infant
Male
Middle Aged
Polymerase Chain Reaction
RNA / metabolism
RNA, Viral / genetics
Renal Dialysis
Reverse Transcriptase Polymerase Chain Reaction
Risk
Thalassemia / therapy
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/Hepatitis B Surface Antigens; 0/RNA, Viral; 63231-63-0/RNA; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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