| GB virus C infection among young, HIV-negative injection drug users with and without hepatitis C virus infection. | |
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MedLine Citation:
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PMID: 20738773 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Summary. Our study examined the association between GB virus C (GBV-C) and (i) hepatitis C virus (HCV) infection status, (ii) biomedical indicators of liver disease (alanine and aspartate aminotransferases) and (iii) HCV RNA level among young injection drug users (IDUs) recruited using street outreach and respondent-driven methods. Cross-sectional and longitudinal analyses were completed. GBV-C (active or resolved) infection was significantly (P < 0.05) more prevalent among HCV antibody-positive (anti-HCV+) (65.1%) than antibody-negative (anti-HCV-) (32.3%) (OR = 3.9, 95% CI: 2.3-6.9) IDUs. The prevalence of resolved GBV-C infection was highest among those with chronic HCV infection (41.9%), followed by those with resolved HCV infection (34.4%) and significantly lower (P < 0.05) among anti-HCV participants (16.9%). Although not statistically significant (P = 0.13), a similar pattern was observed for active GBV-C infection. No association between GBV-C infection status and biomedical indicators of liver disease or HCV RNA level over time was observed. In conclusion, GBV-C infection prevalence was higher among anti-HCV+ compared to anti-HCV- young IDUs, similar to prior studies among older populations. In particular, chronically HCV-infected young IDUs had an increased rate of GBV-C clearance. |
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Authors:
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B Boodram; R C Hershow; D Klinzman; J T Stapleton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of viral hepatitis Volume: 18 ISSN: 1365-2893 ISO Abbreviation: J. Viral Hepat. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435672 Medline TA: J Viral Hepat Country: England |
Other Details:
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Languages: eng Pagination: e153-9 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USA Department of Internal Medicine, Division of Infectious Diseases, Iowa City Veterans Administration and the University of Iowa, Iowa City, IA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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