| GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells. | |
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MedLine Citation:
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PMID: 21670475 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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GATA3 has been identified as a master regulator of T helper cells, as well as being important for early thymic progenitors and T cell commitment. However, Gata3 expression initiates already at the hematopoietic stem cell (HSC) level, implicating a potential role also in regulation of HSCs. Herein we used a conditional Gata3 knockout strategy in which Gata3 expression was completely deleted from the earliest stage of embryonic hematopoietic development after emergence of HSCs from hemogenic endothelium. Through a detailed analysis of HSCs at the phenotypic and functional level, we demonstrate that steady state levels of HSCs are normal in Gata3(fl/fl)Vav-Cre(tg/+) mice. Moreover, through long-term primary and secondary transplantation experiments, we also unequivocally demonstrate that Gata3 has a redundant role in post-transplantation HSC self-renewal. |
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Authors:
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Natalija Buza-Vidas; Sara Duarte; Sidinh Luc; Tiphaine Bouriez-Jones; Petter S Woll; Sten Eirik Waelgaard Jacobsen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-13 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hematopoietic Stem Cell Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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