Document Detail


GATA3 is downregulated during hair cell differentiation in the mouse cochlea.
MedLine Citation:
PMID:  10447238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GATA3 is a transcription factor expressed in the inner ear during the early stages of development. A monoclonal antibody revealed that it is expressed in spiral ganglion cells and in all cells of the developing auditory sensory epithelium in the mouse before the hair cells differentiate at embryonic days 14-16. Expression decreases selectively in the hair cells as they differentiate progressively from the base to the apex of the developing organ of Corti. GATA3 subsequently decreases in the supporting cells and cannot be detected by immunofluorescence in any cell of the adult sensory epithelium. It is not expressed in the vestibular sensory epithelia or surrounding tissues from embryonic day 14. We suggest that GATA3 could act as a repressor of critical genes involved in cell differentiation in the organ of Corti, enabling a progressive formation of the adult cellular pattern.
Authors:
M N Rivolta; M C Holley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurocytology     Volume:  27     ISSN:  0300-4864     ISO Abbreviation:  J. Neurocytol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364620     Medline TA:  J Neurocytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  637-47     Citation Subset:  IM; S    
Affiliation:
Department of Physiology, School of Medical Sciences, University of Bristol, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal
Cell Differentiation
Cochlea / cytology,  embryology*,  metabolism*
DNA-Binding Proteins / genetics,  immunology,  metabolism*
Down-Regulation
Fluorescent Antibody Technique
GATA3 Transcription Factor
Gestational Age
Hair Cells, Auditory / metabolism*,  ultrastructure*
Mice
Mice, Inbred C57BL
Spiral Ganglion / cytology,  embryology,  metabolism,  ultrastructure
Trans-Activators / genetics,  immunology,  metabolism*
Vestibule, Labyrinth / cytology,  embryology,  metabolism,  ultrastructure
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/DNA-Binding Proteins; 0/GATA3 Transcription Factor; 0/Gata3 protein, mouse; 0/Trans-Activators

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