Document Detail

GAS6, the ligand of Axl and Rse receptors, is expressed in hematopoietic tissue but lacks mitogenic activity.
MedLine Citation:
PMID:  9357964     Owner:  NLM     Status:  MEDLINE    
GAS6, a gene previously identified as growth arrest specific, has been demonstrated to be the ligand of Axl, a novel tyrosine kinase receptor widely expressed in both normal and neoplastic hematopoietic tissue. We have observed previously that GAS6 mRNA was present in whole bone marrow. This preliminary finding prompted us to investigate the presence of GAS6 in hematopoietic tissue and the possible role of this molecule in controlling the proliferation of hematopoietic precursors. We report here that the protein GAS6 is diffusely present in hematopoietic tissue, both in stromal and in hematopoietic cells, and that, among these cells, positivity is observed in megakaryocytes and myelomonocytic precursors. Furthermore, our data suggest that GAS6 is not a growth factor for hematopoietic progenitors or stromal fibroblasts. Despite the fact that both the Axl receptor and its ligand, GAS6, are expressed in hematopoietic tissue, the biological role of their interactions remains to be determined.
G C Avanzi; M Gallicchio; G Cavalloni; L Gammaitoni; F Leone; A Rosina; R Boldorini; G Monga; L Pegoraro; B Varnum; M Aglietta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental hematology     Volume:  25     ISSN:  0301-472X     ISO Abbreviation:  Exp. Hematol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2010-06-02    
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1219-26     Citation Subset:  IM    
Dipartimento di Scienze Mediche, Facolt? di Medicina di Novara, Italy.
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MeSH Terms
Bone Marrow Cells / metabolism*
Cell Division / drug effects
Cells, Cultured
Fibroblasts / cytology
Gene Expression
Hematopoietic Cell Growth Factors / pharmacology
Intercellular Signaling Peptides and Proteins*
Oncogene Proteins / physiology
Proteins / genetics,  metabolism*
RNA, Messenger / genetics
Receptor Protein-Tyrosine Kinases / physiology
Recombinant Proteins / pharmacology
Reg. No./Substance:
0/Hematopoietic Cell Growth Factors; 0/Intercellular Signaling Peptides and Proteins; 0/Mitogens; 0/Oncogene Proteins; 0/Proteins; 0/RNA, Messenger; 0/Recombinant Proteins; 0/growth arrest-specific protein 6; EC 2.7.1.-/TYRO3 protein, human; EC Protein-Tyrosine Kinases; EC receptor tyrosine kinase

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