| GAD65 Antibodies, Chronic Psychosis, and Type 2 Diabetes Mellitus. | |
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MedLine Citation:
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PMID: 21922068 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Glutamic acid decarboxylase is the rate-limiting enzyme in the production of gamma aminobutyric acid, an inhibitory neurotransmitter. Autoantibodies to the glutamic acid decarboxylase 65 isoform have been associated with chronic psychotic disorders and are found in neurons and pancreatic islets. Blood samples were collected from normal controls (n=16), individuals with chronic psychosis with type 2 diabetes mellitus (n=3), and patients with chronic psychosis without diabetes (n=8). No differences were found between any of the groups for frequency of positive glutamic acid decarboxylase 65Ab samples (98th percentile of a healthy control group) or in mean values of glutamic acid decarboxylase 65Ab. Sample size was likely too small to detect differences if they do exist. |
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Authors:
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Atmaram Yarlagaclcla; Jerome H Taylor; Christiane S Hampe; Christiane S Hampe; Elizabeth Alfson; Anita H Clayton |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Innovations in clinical neuroscience Volume: 8 ISSN: 2158-8341 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-9-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101549695 Medline TA: Innov Clin Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: 34-36 Citation Subset: - |
Affiliation:
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Dr. Yarlagadda is Assistant Professor, Department of Psychiatry and Neurobehavioral Sciences, Charlottesville, Virginia; Dr. Taylor is from the Yale Child Study Center, New Haven, Connecticut; Dr. Hampe is Research Associate Professor, Department of Medicine, University of Washington, Seattle, Washington; Dr. Alfson is from the Brigham and Women's Hospital, Boston, Massachusetts; and Dr. Clayton is Professor, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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