Document Detail

GAD2 gene sequence variations are associated with eating behaviors and weight gain in women from the Quebec family study.
MedLine Citation:
PMID:  19686769     Owner:  NLM     Status:  MEDLINE    
The glutamate decarboxylase 2 (GAD2) gene encodes for the glutamic acid decarboxylase enzyme (GAD65), which is implicated in the formation of the gamma-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake. The objective of the present study was to test for association between GAD2 single-nucleotide polymorphisms (SNPs) and eating behaviors, dietary intake and obesity in subjects (n=873) from the Quebec Family Study (QFS). Energy and macronutrient intakes were measured using a 3-day dietary record and eating behaviors were assessed using the Three-Factor Eating Questionnaire (TFEQ). Six SNPs capturing about 90% of GAD2 gene variability were genotyped and tested for association with age- and BMI- adjusted phenotypes. No evidence of association was found in men. In women, a SNP (rs992990; c.61450 C>A) was associated with disinhibition (p=0.028), emotional susceptibility to disinhibition (p=0.0005) and susceptibility to hunger (p=0.028). Another SNP (rs7908975; c.8473A>C) was associated with carbohydrate (p=0.021) and lipid (p=0.021) intakes, disinhibition (p=0.011) and two of its subscales (emotional and situational susceptibility) as well as with avoidance of fattening foods (p=0.036). Six-year weight gain was two times higher in women carrying the variants associated with eating behaviors: 4.2kg (vs 2.1kg in non-carriers) in A-allele carriers of c.61450 C>A (p=0.038) and 4.9kg (vs 2.5kg in non-carriers) in C-allele carriers of c. 8473 A>C (p=0.013). The results suggest a role for the GAD2 gene in determining food intake, eating behaviors and weight gain over time in women.
Anne C Choquette; Simone Lemieux; Angelo Tremblay; Vicky Drapeau; Claude Bouchard; Marie-Claude Vohl; Louis Pérusse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-15
Journal Detail:
Title:  Physiology & behavior     Volume:  98     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-18     Completed Date:  2009-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Division of kinesiology, Department of Social and Preventive Medicine, Laval University, Quebec, Canada.
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MeSH Terms
Anthropometry / methods
Body Mass Index
Dietary Supplements
Eating / genetics
Feeding Behavior / physiology*
Food Habits
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation*
Glutamate Decarboxylase / genetics*
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Weight Gain / genetics*
Reg. No./Substance:
EC Decarboxylase; EC decarboxylase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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