Document Detail


GABAergic mechanisms of the lateral parabrachial nucleus on sodium appetite.
MedLine Citation:
PMID:  17562389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GABAergic activation in the lateral parabrachial nucleus (LPBN) induces sodium and water intake in satiated and normovolemic rats. In the present study we investigated the effects of GABAA receptor activation in the LPBN on 0.3M NaCl, water, 2% sucrose and food intake in rats submitted to sodium depletion (treatment with the diuretic furosemide subcutaneously+sodium deficient food for 24h), 24h food deprivation or 24 h water deprivation. Male Holtzman rats with bilateral stainless steel cannulas implanted into the LPBN were used. In sodium depleted rats, muscimol (GABAA receptor agonist, 0.5 nmol/0.2 microl), bilaterally injected into the LPBN, produced an inconsistent increase of water intake and two opposite effects on 0.3M NaCl intake: an early inhibition (4.3+/-2.7 versus saline: 14.4+/-1.0 ml/15 min) and a late facilitation (37.6+/-2.7 versus saline: 21.1+/-0.9 ml/180 min). The pretreatment of the LPBN with bicuculline (GABAA receptor antagonist, 1.6 nmol) abolished these effects of muscimol. Muscimol into the LPBN also reduced food deprivation-induced food intake in the first 30 min of test (1.7+/-0.6g versus saline: 4.1+/-0.6g), without changing water deprivation-induced water intake or 2% sucrose intake in sodium depleted rats. Therefore, although GABAA receptors in the LPBN are not tonically involved in the control of sodium depletion-induced sodium intake, GABAA receptor activation in the LPBN produces an early inhibition and a late facilitation of sodium depletion-induced sodium intake. GABAA activation in the LPBN also inhibits food intake, while it consistently increases only sodium intake and not water, food or sucrose intake.
Authors:
Lisandra B de Oliveira; João C Callera; Laurival A De Luca; Débora S A Colombari; José V Menani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-04-03
Journal Detail:
Title:  Brain research bulletin     Volume:  73     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-12     Completed Date:  2008-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-47     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pathology, School of Dentistry, UNESP, Rua Humaitá 1680, 14801-903 Araraquara, SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite*
Bicuculline / pharmacology
Diuretics / pharmacology
Drinking / physiology
Eating / physiology
Food Deprivation
Furosemide / pharmacology
GABA Agonists / metabolism,  pharmacology
GABA Antagonists / metabolism,  pharmacology
Male
Muscimol / metabolism,  pharmacology
Organophosphorus Compounds / pharmacology
Pons* / anatomy & histology,  drug effects,  metabolism
Rats
Rats, Inbred Strains
Receptors, GABA-A / metabolism*
Sodium Chloride* / administration & dosage,  metabolism
Sodium, Dietary / metabolism*
Water Deprivation
gamma-Aminobutyric Acid / metabolism*
Chemical
Reg. No./Substance:
0/Diuretics; 0/GABA Agonists; 0/GABA Antagonists; 0/Organophosphorus Compounds; 0/Receptors, GABA-A; 0/Sodium, Dietary; 123690-79-9/CGP 35348; 2763-96-4/Muscimol; 485-49-4/Bicuculline; 54-31-9/Furosemide; 56-12-2/gamma-Aminobutyric Acid; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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