| GABAergic inhibition influences auditory motion-direction sensitivity in barn owls. | |
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MedLine Citation:
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PMID: 9658039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many neurons in the barn owl's inferior colliculus (IC) exhibit auditory motion-direction sensitivity (MDS), i.e., they respond more to motion of a sound source in one direction than to motion in the opposite direction. We investigated the cellular mechanisms underlying the phenomenon of auditory MDS by microiontophoretically applying gamma-aminobutyric acid (GABA) or the GABA-antagonist bicuculline methiodide (BMI) while recording from neurons in the owl's midbrain. In most cases GABA reduced the overall firing rate, whereas BMI increased it. In addition, 29% of the motion-direction-sensitive cells completely lost their selectivity for the direction of auditory movement during administration of BMI. It had been proposed that auditory MDS in the owl is due to inhibition. The present results show that GABAergic inhibition plays a role in the strengthening of MDS. We discuss the data within the framework of the acoustic motion detector and with respect to microiontophoretic studies on visual motion detection and on inhibitory mechanisms in the inferior colliculus. |
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Authors:
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D Kautz; H Wagner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurophysiology Volume: 80 ISSN: 0022-3077 ISO Abbreviation: J. Neurophysiol. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-08-25 Completed Date: 1998-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 172-85 Citation Subset: IM |
Affiliation:
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Max-Planck-Institut für biologische Kybernetik, D-72076 Tübingen, Germany and Institut für Zoologie, Technische Universität München, D-85747 Garching, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Auditory Perception / physiology* Bicuculline / analogs & derivatives, pharmacology Birds / physiology* GABA Antagonists / pharmacology Inferior Colliculi / physiology* Mesencephalon / drug effects, physiology* Models, Neurological Motor Activity / physiology* Neurons / physiology* Reaction Time / drug effects Regression Analysis Superior Colliculi / physiology* gamma-Aminobutyric Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/GABA Antagonists; 40709-69-1/bicuculline methiodide; 485-49-4/Bicuculline; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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