| A GABAergic component in the commissure of the inferior colliculus in rat. | |
| | |
MedLine Citation:
|
PMID: 17001278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The commissure of the inferior colliculus is significant as the final point of interconnection between homologous structures on the two sides of the auditory pathway at the subcortical level. The presence of excitatory fibres is well established in this tract, but the existence of an inhibitory component is controversial. Using rats, we injected biotinylated dextran amine into the inferior colliculus on one side to retrogradely label cells projecting through the commissure from the contralateral inferior colliculus. Immunocytochemistry for gamma-amino-n-butyric acid in neighbouring semithin sections revealed that 20% of biotinylated dextran amine cell profiles were also labelled for gamma-amino-n-butyric acid. We conclude that monosynaptic inhibitory connections contribute to the inhibition observed in the contralateral inferior colliculus in functional studies of the commissural projection. |
| | |
Authors:
|
Olga Hernández; Adrian Rees; Manuel S Malmierca |
Related Documents
:
|
8039478 - Tiagabine: a novel drug with a gabaergic mechanism of action. 10206328 - Effects of crude venom, tityustoxin and toxin ts-gamma from tityus serrulatus scorpion ... 11738238 - Detection of vitamin k-dependent proteins in venoms with a monoclonal antibody specific... 6244038 - Influence of cellular transport on the interaction of amino acids with gamma-aminobutyr... 6185338 - Induction of sporulation in bacillus brevis. 2. dependence on the presence of the pepti... 21915958 - How to distinguish between cinnamoylshikimate esters and chlorogenic acid lactones by l... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroreport Volume: 17 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-26 Completed Date: 2007-03-28 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
|
Languages: eng Pagination: 1611-4 Citation Subset: IM |
Affiliation:
|
Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute for Neuroscience of Castilla y León, University of Salamanca, Salamanca, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Auditory Pathways / metabolism* Biotin / analogs & derivatives, metabolism Dextrans / metabolism Female Functional Laterality / physiology* Immunohistochemistry / methods Inferior Colliculi / metabolism* Male Rats Rats, Long-Evans gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/biotinylated dextran amine; 56-12-2/gamma-Aminobutyric Acid; 58-85-5/Biotin; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A role for the inferior colliculus in multisensory speech integration.
Next Document: The role of spinal nuclear factor-kappa B in spinal hyperexcitability.