Document Detail


GABARAP is overexpressed in colorectal carcinoma and correlates with shortened patient survival.
MedLine Citation:
PMID:  20583424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP), the mammalian homologue of yeast Atg8, is involved in autophagosome formation during autophagy. The aim of this study is to explore the expression and its prognostic significance in comparison with various clinicopathological predictors of survival. METHODOLOGY: GABARAP protein expression was determined by immunohistochemistry in 103 colorectal cancers. Cytoplasmic immunoreactivity was scored semiquantitatively. The results were analyzed in correlation with various clinicopathological variables, including patient survival. Chi-square test and Kaplan-Meier survival analysis were applied. RESULTS: The expression of GABARAP was significantly higher in colorectal cancers than that in adjacent matched nontumor tissues (51.5% vs 33.0%, p < 0.01). Increased expression of GABARAP expression in colorectal cancers was significantly correlated with a low grade of differentiation and shortened overall survival (p < 0.05). There were no significant differences between the expression of GABARAP and age, gender, stage, tumor size, location of primary tumor, and lymph node invasion. CONCLUSIONS: Our data demonstrated that GABARAP is frequently expressed in colorectal cancer. Overexpression of GABARAP is a new independent prognostic marker, which is associated with poor differentiation as well as shortened overall survival.
Authors:
Yufeng Miao; Youwei Zhang; Yonglin Chen; Longbang Chen; Fangyu Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  57     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Affiliation:
Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / metabolism*
Adult
Aged
Aged, 80 and over
Chi-Square Distribution
Colorectal Neoplasms / metabolism*,  pathology
Female
Humans
Immunohistochemistry
Male
Microtubule-Associated Proteins / metabolism*
Middle Aged
Neoplasm Staging
Prognosis
Survival Analysis
Tumor Markers, Biological / metabolism
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/GABARAP protein, human; 0/Microtubule-Associated Proteins; 0/Tumor Markers, Biological

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