Document Detail

GABARAP is overexpressed in colorectal carcinoma and correlates with shortened patient survival.
MedLine Citation:
PMID:  20583424     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP), the mammalian homologue of yeast Atg8, is involved in autophagosome formation during autophagy. The aim of this study is to explore the expression and its prognostic significance in comparison with various clinicopathological predictors of survival. METHODOLOGY: GABARAP protein expression was determined by immunohistochemistry in 103 colorectal cancers. Cytoplasmic immunoreactivity was scored semiquantitatively. The results were analyzed in correlation with various clinicopathological variables, including patient survival. Chi-square test and Kaplan-Meier survival analysis were applied. RESULTS: The expression of GABARAP was significantly higher in colorectal cancers than that in adjacent matched nontumor tissues (51.5% vs 33.0%, p < 0.01). Increased expression of GABARAP expression in colorectal cancers was significantly correlated with a low grade of differentiation and shortened overall survival (p < 0.05). There were no significant differences between the expression of GABARAP and age, gender, stage, tumor size, location of primary tumor, and lymph node invasion. CONCLUSIONS: Our data demonstrated that GABARAP is frequently expressed in colorectal cancer. Overexpression of GABARAP is a new independent prognostic marker, which is associated with poor differentiation as well as shortened overall survival.
Yufeng Miao; Youwei Zhang; Yonglin Chen; Longbang Chen; Fangyu Wang
Related Documents :
7521264 - Neuroendocrine differentiation as a prognostic factor in non-small cell lung cancer.
19725224 - Bcl-2 in combination to myeloid antigen expression in adult acute lymphoblastic leukemi...
16261844 - Bcl-2 as prognostic factor in head and neck squamous cell carcinoma.
134274 - Angio-immunoblastic lymphadenitis: remarks about two cases.
24885654 - Total thyroidectomy without prophylactic central neck dissection in clinically node-neg...
18716594 - In-house auto cutoff sensor device for radiotherapy machine to monitor patient movements.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  57     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptor Proteins, Signal Transducing / metabolism*
Aged, 80 and over
Chi-Square Distribution
Colorectal Neoplasms / metabolism*,  pathology
Microtubule-Associated Proteins / metabolism*
Middle Aged
Neoplasm Staging
Survival Analysis
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/GABARAP protein, human; 0/Microtubule-Associated Proteins; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The role of pRB, p16 and cyclin D1 in colonic carcinogenesis.
Next Document:  Ligation of oesophageal varices may increase formation of "deep" gastric collaterals.