Document Detail

GABA(A) and dopamine receptors in the nucleus accumbens shell differentially influence performance of a water-reinforced progressive ratio task.
MedLine Citation:
PMID:  22155440     Owner:  NLM     Status:  MEDLINE    
Several authors have shown that injections of the GABA(A) agonist muscimol into the medial shell region of the nucleus accumbens (AcbSh) result in large increases in food, but not water, intake. In previous studies we demonstrated that intra-AcbSh injections of either muscimol or of the indirect dopamine agonist amphetamine increase response output on a food-reinforced progressive ratio schedule. In the current experiment we extended these observations by examining the effects of muscimol and amphetamine injections on the performance of a water-reinforced progressive ratio task in mildly deprived animals. We found that muscimol did not affect the number of responses made in the water-reinforced task, even though a marked increase in responding was observed after amphetamine. Muscimol did, however, significantly increase food intake in the same animals. The results suggest that the enhancing effects of intra-AcbSh muscimol differ from those of amphetamine in that they are selective for food-reinforced behaviors.
Ignacio R Covelo; David Wirtshafter; Thomas R Stratford
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-12-01
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  101     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-05-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Laboratory of Integrative Neuroscience and Department of Psychology, University of Illinois at Chicago, 1007 W. Harrison St., M/C 285, Chicago, IL 60607-7137, United States.
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MeSH Terms
Amphetamine / administration & dosage,  pharmacology
Conditioning, Operant / physiology*
Dopamine Uptake Inhibitors / administration & dosage,  pharmacology
Eating / drug effects
Food Deprivation
GABA Agonists / administration & dosage,  pharmacology
Muscimol / administration & dosage,  pharmacology
Nucleus Accumbens / physiology*
Rats, Sprague-Dawley
Receptors, Dopamine / physiology*
Receptors, GABA-A / physiology*
Reinforcement (Psychology)
Reinforcement Schedule
Grant Support
R01 DK071738-04/DK/NIDDK NIH HHS; R01DK071738/DK/NIDDK NIH HHS; R03 DA020802-02/DA/NIDA NIH HHS; R03DA020802/DA/NIDA NIH HHS
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 0/GABA Agonists; 0/Receptors, Dopamine; 0/Receptors, GABA-A; 2763-96-4/Muscimol; 300-62-9/Amphetamine; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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