| GABAA-benzodiazepine-chloride receptor-targeted therapy for tinnitus control: preliminary report. | |
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MedLine Citation:
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PMID: 14763233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our goal was to attempt to establish neuropharmacological tinnitus control (i.e., relief) with medication directed to restoration of a deficiency in the gamma-aminobutyric acid-benzodiazepine-chloride receptor in tinnitus patients with a diagnosis of a predominantly central type tinnitus. Thirty tinnitus patients completed a medical audiological tinnitus patient protocol and brain magnetic resonance imaging and single-photon emission computed tomography of brain. Treatment with GABAergic and benzodiazepine medication continued for 4-6 weeks. A maintenance dose was continued when tinnitus control was positive. Intake and outcome questionnaires were completed. Of 30 patients, 21 completed the trial (70%). Tinnitus control lasting from 4-6 weeks to 3 years was reported by 19 of the 21 (90%). The trial was not completed by 9 of the 30 (30%). No patient experienced an increase in tinnitus intensity or annoyance. Sequential brain single-photon emission computed tomography in 10 patients revealed objective evidence of increased brain perfusion. Patients with a predominantly central type tinnitus experience significant tinnitus control with medication directed to the gamma-aminobutyric acid-benzodiazepine-chloride receptor. |
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Authors:
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Abraham Shulman; Arnold M Strashun; Barbara A Goldstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The international tinnitus journal Volume: 8 ISSN: 0946-5448 ISO Abbreviation: Int Tinnitus J Publication Date: 2002 |
Date Detail:
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Created Date: 2004-02-06 Completed Date: 2004-02-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9612993 Medline TA: Int Tinnitus J Country: United States |
Other Details:
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Languages: eng Pagination: 30-6 Citation Subset: IM |
Affiliation:
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Martha Entenmann Tinnitus Research Center, Health Science Center at Brooklyn, State University of New York, Box 1239, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. metrc@inch.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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administration & dosage,
therapeutic use Adult Aged Aged, 80 and over Amines* Benzodiazepines / administration & dosage, pharmacology, therapeutic use* Chloride Channels / drug effects*, metabolism Clonazepam / administration & dosage, therapeutic use Cyclohexanecarboxylic Acids* Female GABA Agents / administration & dosage, pharmacology, therapeutic use* Humans Instillation, Drug Magnetic Resonance Imaging Male Middle Aged Questionnaires Receptors, GABA / drug effects*, physiology Receptors, GABA-A / drug effects, physiology Tinnitus / drug therapy*, psychology Tomography, Emission-Computed, Single-Photon gamma-Aminobutyric Acid* |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Amines; 0/Chloride Channels; 0/Cyclohexanecarboxylic Acids; 0/GABA Agents; 0/Receptors, GABA; 0/Receptors, GABA-A; 12794-10-4/Benzodiazepines; 1622-61-3/Clonazepam; 56-12-2/gamma-Aminobutyric Acid; 60142-96-3/gabapentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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