| GABA(A) receptor modulation during adolescence alters adult ethanol intake and preference in rats. | |
| | |
MedLine Citation:
|
PMID: 21895721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: To address the hypothesis that GABA(A) receptor modulation during adolescence may alter the abuse liability of ethanol during adulthood, the effects of adolescent administration of both a positive and negative GABA(A) receptor modulator on adult alcohol intake and preference were assessed. METHODS: Three groups of adolescent male rats received 12 injections of lorazepam (3.2 mg/kg), dehydroepiandrosterone (DHEA, 56 mg/kg), or vehicle on alternate days starting on postnatal day (PD) 35. After this time, the doses were increased to 5.6 and 100 mg/kg, respectively, for 3 more injections on alternate days. Subjects had access to 25 to 30 g of food daily, during the period of the first 6 injections, and 18 to 20 g thereafter. Food intake of each group was measured 60 minutes after food presentation, which occurred immediately after drug administration on injection days or at the same time of day on noninjection days. When subjects reached adulthood (PD 88), ethanol preference was determined on 2 separate occasions, an initial 3-day period and a 12-day period, in which increasing concentrations of ethanol were presented. During each preference test, intake of water, saccharin, and an ethanol/saccharin solution was measured after each 23-hour access period. RESULTS: During adolescence, lorazepam increased 60-minute food intake, and this effect was enhanced under the more restrictive feeding schedule. DHEA had the opposite effect on injection days, decreasing food intake compared with noninjection days. In adulthood, the lorazepam-treated group preferred the 2 lowest concentrations of ethanol/saccharin more than saccharin alone compared with vehicle-treated subjects, which showed no preference for any concentration of ethanol/saccharin over saccharin. DHEA-treated subjects showed no preference among the 3 solutions. CONCLUSIONS: These data demonstrate that GABA(A) receptor modulation during adolescence can alter intake and preference for ethanol in adulthood and highlights the importance of drug history as an important variable in the liability for alcohol abuse. |
| | |
Authors:
|
Mary W Hulin; Russell J Amato; Peter J Winsauer |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-09-06 |
Journal Detail:
|
Title: Alcoholism, clinical and experimental research Volume: 36 ISSN: 1530-0277 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-30 Completed Date: 2012-05-17 Revised Date: 2013-04-08 |
Medline Journal Info:
|
Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: England |
Other Details:
|
Languages: eng Pagination: 223-33 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 by the Research Society on Alcoholism. |
Affiliation:
|
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Science Center, New Orleans, Louisiana, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Alcohol Drinking / psychology* Animals Data Interpretation, Statistical Dehydroepiandrosterone / pharmacology Dose-Response Relationship, Drug Eating / drug effects Lorazepam / pharmacology Male Rats Rats, Long-Evans Receptors, GABA-A / drug effects* Saccharin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
AA019848/AA/NIAAA NIH HHS; F30 AA019848-01/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, GABA-A; 53-43-0/Dehydroepiandrosterone; 81-07-2/Saccharin; 846-49-1/Lorazepam |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alcohol Dehydrogenase-1B Arg47His Polymorphism and Upper Aerodigestive Tract Cancer Risk: A Meta-Ana...
Next Document: The effects of age at drinking onset and stressful life events on alcohol use in adulthood: a replic...