| GABA signalling during development: new data and old questions. | |
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MedLine Citation:
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PMID: 11545261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to being the major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is thought to play a morphogenetic role in embryonic development. During the last decade, considerable progress has been made in elucidating the molecular mechanisms involved in GABA synthesis and biological action. The present review is an attempt to summarise recent results on the ontogeny of the different components of embryonic GABA signalling with an emphasis on the synthesis of GABA by different molecular forms of glutamic acid decarboxylase (GAD). |
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Authors:
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P Varju; Z Katarova; E Madarász; G Szabó |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cell and tissue research Volume: 305 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-09-06 Completed Date: 2002-01-24 Revised Date: 2006-11-20 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 239-46 Citation Subset: IM |
Affiliation:
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Laboratory of Neural Cell Biology, Institute of Experimental Medicine, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / metabolism Cell Division Cell Membrane / metabolism Cell Movement Central Nervous System / embryology, metabolism, physiology GABA Plasma Membrane Transport Proteins Glutamate Decarboxylase / genetics, metabolism* Growth Cones / metabolism Humans Membrane Proteins / metabolism Membrane Transport Proteins* Mutagenesis Neurons / cytology, physiology Organic Anion Transporters* Signal Transduction / physiology* Stem Cells / cytology, physiology gamma-Aminobutyric Acid / biosynthesis, metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/GABA Plasma Membrane Transport Proteins; 0/Membrane Proteins; 0/Membrane Transport Proteins; 0/Organic Anion Transporters; 56-12-2/gamma-Aminobutyric Acid; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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