| GABA-like immunoreactivity in the vertebrate retina: a species comparison. | |
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MedLine Citation:
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PMID: 3487464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rabbit antisera directed against gamma-amino butyric acid (GABA) conjugated to bovine serum albumin was used to localize neurons containing GABA-like immunoreactivity in the retinas of nine species of animals: human, cat, rabbit, rat, chicken, turtle, frog, mudpuppy and goldfish. The retinas of all species contained GABA-like labeling in several populations of amacrine cells in the inner nuclear layer, cells in the ganglion-cell layer that may include displaced amacrine cells and in fibers in the inner plexiform layer and in the optic nerve fiber layer. Labeled horizontal cells were found in cat and in all non-mammalian retinas. Labeled interplexiform cells were found in rat, rabbit, cat and human retinas. Labeled bipolar cells were restricted to frog and mudpuppy retinas. The distribution of anti-GABA is usually similar to that of anti-glutamic acid decarboxylase and neuronal [3H]GABA uptake, indicating good correspondence between these 'GABAergic' markers. However, several significant differences among these markers are discussed. |
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Authors:
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J L Mosinger; S Yazulla; K M Studholme |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental eye research Volume: 42 ISSN: 0014-4835 ISO Abbreviation: Exp. Eye Res. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-08-18 Completed Date: 1986-08-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 631-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Chickens Goldfish Humans Necturus maculosus Neurons / immunology Optic Nerve / immunology Rabbits Rana pipiens Rats Retina / immunology* Retinal Ganglion Cells / immunology Turtles gamma-Aminobutyric Acid / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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EY01682/EY/NEI NIH HHS; EY05683/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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