Document Detail

GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.
MedLine Citation:
PMID:  23389926     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: GABA damages large, but not small, cholangiocytes that differentiate into large cholangiocytes. The differentiation of small into large cholangiocytes may be important in the replenishment of the biliary epithelium during damage of large, senescent cholangiocytes.
Romina Mancinelli; Antonio Franchitto; Shannon Glaser; Fanyin Meng; Paolo Onori; Sharon Demorrow; Heather Francis; Julie Venter; Guido Carpino; Kimberley Baker; Yuyan Han; Yoshiyuki Ueno; Eugenio Gaudio; Gianfranco Alpini
Related Documents :
2985056 - Na+/h+ exchanger activity in the pig kidney epithelial cell line, llc-pk1: inhibition b...
8268116 - Chronic exposure to lidocaine does not alter flux through sodium channels in cultured n...
19326446 - Identification and functional characterization of the promoter of the mouse sodium-acti...
24997896 - Formulation of an alginate-vineyard pruning waste composite as a new eco-friendly adsor...
2448636 - Expression of functional potassium channels from shaker cdna in xenopus oocytes.
12235216 - Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular tr...
Publication Detail:
Type:  Journal Article     Date:  2013-05-14
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenylate Cyclase / metabolism*
Apoptosis / drug effects
Bile Ducts, Intrahepatic / cytology*,  drug effects
Calcium-Calmodulin-Dependent Protein Kinase Type 1 / metabolism
Cell Differentiation / drug effects*
Cell Proliferation / drug effects
Cyclic AMP / metabolism
Egtazic Acid / analogs & derivatives,  pharmacology
GABA Antagonists / pharmacology
Mice, Inbred C57BL
Signal Transduction / drug effects
Sulfonamides / pharmacology
gamma-Aminobutyric Acid / pharmacology*
Grant Support
Reg. No./Substance:
0/GABA Antagonists; 0/Sulfonamides; 139890-68-9/1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester; 526U7A2651/Egtazic Acid; 56-12-2/gamma-Aminobutyric Acid; 65595-90-6/W 7; E0399OZS9N/Cyclic AMP; EC Protein Kinase Type 1; EC Cyclase; EC cyclase 8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hip Fractures in People With Idiopathic Parkinson's Disease: Incidence and Outcomes.
Next Document:  Fmoc-based peptide thioester synthesis with self-purifying effect: heading to native chemical ligati...