Document Detail


GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.
MedLine Citation:
PMID:  23389926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: GABA damages large, but not small, cholangiocytes that differentiate into large cholangiocytes. The differentiation of small into large cholangiocytes may be important in the replenishment of the biliary epithelium during damage of large, senescent cholangiocytes.
Authors:
Romina Mancinelli; Antonio Franchitto; Shannon Glaser; Fanyin Meng; Paolo Onori; Sharon Demorrow; Heather Francis; Julie Venter; Guido Carpino; Kimberley Baker; Yuyan Han; Yoshiyuki Ueno; Eugenio Gaudio; Gianfranco Alpini
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Publication Detail:
Type:  Journal Article     Date:  2013-05-14
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / metabolism*
Animals
Apoptosis / drug effects
Bile Ducts, Intrahepatic / cytology*,  drug effects
Calcium-Calmodulin-Dependent Protein Kinase Type 1 / metabolism
Cell Differentiation / drug effects*
Cell Proliferation / drug effects
Cyclic AMP / metabolism
Egtazic Acid / analogs & derivatives,  pharmacology
GABA Antagonists / pharmacology
Ligation
Male
Mice
Mice, Inbred C57BL
Signal Transduction / drug effects
Sulfonamides / pharmacology
gamma-Aminobutyric Acid / pharmacology*
Grant Support
ID/Acronym/Agency:
R01 DK062975/DK/NIDDK NIH HHS; R01 DK076898/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/GABA Antagonists; 0/Sulfonamides; 139890-68-9/1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester; 526U7A2651/Egtazic Acid; 56-12-2/gamma-Aminobutyric Acid; 65595-90-6/W 7; E0399OZS9N/Cyclic AMP; EC 2.7.11.17/Calcium-Calmodulin-Dependent Protein Kinase Type 1; EC 4.6.1.1/Adenylate Cyclase; EC 4.6.1.1/adenylyl cyclase 8
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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