Document Detail


GABA-immunoreactive starburst amacrine cells in pigmented and albino rats.
MedLine Citation:
PMID:  15579175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we tested whether the critical anatomical substrate for retinal direction selectivity is altered in albino mammals. We used dual immunostaining for GABA and choline acetyltransferase and quantitatively analyzed the number of double-labelled starburst amacrine cells in wild-type and albino rats. In albino rats, the percentage of ON-amacrine cells with high GABA content was significantly lower than in pigmented animals. OFF-amacrines did not significantly differ between the two rat strains. Thus, the decreased GABA content in ON-amacrine cells could reflect an altered neuronal substrate for retinal direction selectivity. These results are discussed in relation to the optokinetic deficits described in albino mammals.
Authors:
W M Blaszczyk; I Telkes; C Distler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  20     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-06     Completed Date:  2005-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  3195-8     Citation Subset:  IM    
Affiliation:
Allgemeine Zoologie und Neurobiologie, Ruhr-Universität Bochum, Postfach 102148, D-44780 Bochum, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amacrine Cells / metabolism*
Animals
Choline O-Acetyltransferase / metabolism
Immunohistochemistry
Rats
Rats, Long-Evans
Rats, Wistar
Retina / cytology*
Species Specificity
gamma-Aminobutyric Acid / metabolism*
Chemical
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; EC 2.3.1.6/Choline O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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