Document Detail


GABA and hepatocellular carcinoma.
MedLine Citation:
PMID:  10888234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Data derived from models of hepatic regeneration indicate that transient, reciprocal changes in polyamines, potent growth promoters, and gamma aminobutyric acid (GABA), an amino acid neurotransmitter with growth inhibitory properties, play important roles in enhancing and inhibiting respectively regulated hepatocyte proliferation. Based on these findings and supportive data derived from studies of human carcinoma tissues and malignant cell lines we propose that permanent increases in polyamine and decreases in GABAergic activity act in concert to contribute to the pathogenesis of hepatocellular carcinoma.
Authors:
G Y Minuk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  207     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-10-04     Completed Date:  2000-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  105-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Hepatocellular / metabolism*
Humans
Liver / metabolism
Liver Neoplasms / metabolism*
Liver Regeneration
Models, Biological
gamma-Aminobutyric Acid / physiology*
Chemical
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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