| GABA and hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 10888234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Data derived from models of hepatic regeneration indicate that transient, reciprocal changes in polyamines, potent growth promoters, and gamma aminobutyric acid (GABA), an amino acid neurotransmitter with growth inhibitory properties, play important roles in enhancing and inhibiting respectively regulated hepatocyte proliferation. Based on these findings and supportive data derived from studies of human carcinoma tissues and malignant cell lines we propose that permanent increases in polyamine and decreases in GABAergic activity act in concert to contribute to the pathogenesis of hepatocellular carcinoma. |
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Authors:
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G Y Minuk |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 207 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-10-04 Completed Date: 2000-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 105-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Manitoba, Winnipeg, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / metabolism* Humans Liver / metabolism Liver Neoplasms / metabolism* Liver Regeneration Models, Biological gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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